Citric Acid

Citric Acid

SCHEMBL7921329

O=C(O)CC(O)(CC(=O)O)C(=O)O.[Ge]

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.41
ALDH1A1 P00352 2/20 0.94
HMGCR P04035 1/20 0.48
CHRM1 P11229 1/20 0.48
TBXA2R P21731 1/20 0.48
ADRA1A P35348 1/20 0.48
TSHR P16473 2/20 0.46
CYP2D6 P10635 2/20 0.46
CYP2C19 P33261 1/20 0.46
HIF1A Q16665 1/20 0.46
ACLY P53396 4/20 0.44
KDM4E B2RXH2 2/20 0.43
LMNA P02545 2/20 0.43
MAPT P10636 1/20 0.43
ALOX15 P16050 1/20 0.43
SLC13A5 Q86YT5 4/20 0.42
CPT2 P23786 1/20 0.42
CYP1A2 P05177 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL4958371 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL28641702 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL3417188 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL842 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL1332229 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL725546 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL1331942 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL240402 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL10896997 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL6889857 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118751156-A Spray pyrolysis system and application thereof 广东邦普循环科技有限公司 2024-10-11 CN claimed
EP-4464307-A1 COSMETIC COMPOSITION AND METHODS OF MAKING THE SAME MPLUS COSMETICS S.R.L. (IT) 2024-11-20 EP disclosed
US-20240374498-A1 COSMETIC COMPOSITION AND METHODS OF MAKING THE SAME MPLUS COSMETICS S.R.L. (IT) 2024-11-14 US disclosed
CN-118751156-A Spray pyrolysis system and application thereof 广东邦普循环科技有限公司 2024-10-11 CN disclosed
CN-111133619-B Metal-air battery 学校法人神奈川大学 2023-05-05 CN disclosed
CN-115275209-B High-first-efficiency silicon cathode with stable structure, preparation method and lithium ion battery 四川启睿克科技有限公司 2023-03-10 CN disclosed
CN-115275209-A High-first-efficiency silicon cathode with stable structure, preparation method and lithium ion battery 四川启睿克科技有限公司 2022-11-01 CN disclosed
US-20200259187-A1 POSITIVE-ELECTRODE CATALYST FOR METAL-AIR BATTERY, AND METAL-AIR BATTERY KANAGAWA UNIVERSITY (JP) 2020-08-13 US disclosed
CN-111133619-A Positive electrode catalyst for metal-air battery and metal-air battery 学校法人神奈川大学 2020-05-08 CN disclosed
US-9245779-B2 Method of preparing thin film, thin film, apparatus for preparing thin film, and electronic device including thin film SAMSUNG ELECTRONICS CO., LTD. (KR) 2016-01-26 US disclosed
WO-2015020439-A1 GERMANIUM ION WATER PRODUCING METHOD AND CROP CULTIVATING METHOD USING GERMANIUM ION WATER PARK MAN JO (KR) 2015-02-12 WO disclosed
US-20130034708-A1 METHOD OF PREPARING THIN FILM, THIN FILM, APPARATUS FOR PREPARING THIN FILM, AND ELECTRONIC DEVICE INCLUDING THIN FILM SAMSUNG DISPLAY CO., LTD. (KR) 2013-02-07 US disclosed
WO-2001056694-A1 ESTERIFICATION CATALYST COMPOSITIONS ACMA LIMITED (GB) 2001-08-09 WO disclosed
CN-1106210-A Synergist of thuricide powder and its prodn. method WANG CHENGQIU (CN) 1995-08-09 CN disclosed
US-4490299-A TREATING AGENT FOR A CRACKING CATALYST PHILLIPS PETROLEUM COMPANY (US) 1984-12-25 US disclosed
US-4439536-A Hydrocarbon cracking catalyst PHILLIPS PETROLEUM COMPANY (US) 1984-03-27 US disclosed
US-4386015-A TREATING AGENT IS GERMANIUM OR COMPOUNDS OF GERMANIUM PHILLIPS PETROLEUM COMPANY (US) 1983-05-31 US disclosed
US-4334979-A TO PASSIVATE METAL DEPOSITS AND INCREASE YIELD OF GASOLINE PHILLIPS PETROLEUM COMPANY (US) 1982-06-15 US disclosed