Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8922195 | 0.89 | PTPN1 (0.62) | POLBNPC1RAB9ATDP1MEN1 | |
| SCHEMBL21510762 | 0.87 | PTPN1 (0.66) | SIRT1POLBNPC1RAB9ATDP1 | |
| SCHEMBL7920846 | 0.86 | POLB (0.76) | POLBNPC1RAB9ATDP1MEN1 | |
| SCHEMBL8920588 | 0.84 | PTPN1 (0.52) | POLBNPC1RAB9ATDP1MEN1 | |
| SCHEMBL9182279 | 0.82 | NPC1 (0.50) | POLBNPC1RAB9ATDP1MEN1 | |
| SCHEMBL7922647 | 0.80 | KMT2A (0.68) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL12010921 | 0.79 | SIRT1 (0.92) | SIRT1POLBNPC1RAB9ATDP1 | |
| SCHEMBL12113118 | 0.79 | SIRT1 (0.92) | SIRT1POLBNPC1RAB9ATDP1 | |
| SCHEMBL19501815 | 0.75 | SIRT1 (1.00) | SIRT1POLBNPC1RAB9ATDP1 | |
| SCHEMBL8887300 | 0.75 | SMN1; SMN2 (0.59) | POLBNPC1RAB9ATDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019419-A4 | PHOSPHONATED AGENTS AND THEIR ANTIANGIOGENIC AND ANTITUMORIGENIC USE | UNIV KENTUCKY RES FOUND (US) | 2001-12-12 | — | — | EP | disclosed |
| US-6160166-A | Phosphonated agents and their antiangiogenic and antitumorigenic use | THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2000-12-12 | — | — | US | disclosed |
| US-6096730-A | Phosphonated agents and their antiangiogenic and antitumorigenic use | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2000-08-01 | — | — | US | disclosed |
| EP-1019419-A1 | PHOSPHONATED AGENTS AND THEIR ANTIANGIOGENIC AND ANTITUMORIGENIC USE | The University of Kentucky Research Foundation (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999005148-A1 | PHOSPHONATED AGENTS AND THEIR ANTIANGIOGENIC AND ANTITUMORIGENIC USE | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 1999-02-04 | — | — | WO | disclosed |