SCHEMBL7922518

SCHEMBL7922518

CCOc1ccc(CCCCC(F)(F)F)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 1/20 0.48
MAPT P10636 2/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
RAB9A P51151 1/20 0.47
SIGMAR1 Q99720 1/20 0.43
LMNA P02545 2/20 0.42
LTA4H P09960 1/20 0.42
GAA P10253 1/20 0.42
TSHR P16473 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
KMT2A Q03164 2/20 0.41
ALDH1A1 P00352 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
MEN1 O00255 1/20 0.41
USP2 O75604 1/20 0.41
CYP3A4 P08684 1/20 0.41
MAPK1 P28482 1/20 0.41
CASP1 P29466 1/20 0.41
SLCO1B3 Q9NPD5 1/20 0.41
SLCO1B1 Q9Y6L6 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4248652 0.85 NQO1 (0.67) NQO1MAPTL3MBTL1RAB9ASIGMAR1
SCHEMBL7930472 0.84 MAOB (0.41) MAPTLTA4HALDH1A1CALM1
SCHEMBL6650023 0.84 ALDH1A1 (0.57) RAB9ALMNALTA4HKMT2AALDH1A1
SCHEMBL6652134 0.84 ALDH1A1 (0.57) RAB9ALMNALTA4HKMT2AALDH1A1
SCHEMBL10575040 0.83 NQO1 (0.64) NQO1MAPTL3MBTL1RAB9ASIGMAR1
SCHEMBL19197282 0.82 ALDH1A1 (0.58) LMNAKMT2AALDH1A1SMN1; SMN2MEN1
SCHEMBL20151741 0.81 LMNA (0.50) L3MBTL1LMNALTA4HKMT2AALDH1A1
SCHEMBL6652305 0.81 CALM1 (0.58) L3MBTL1SIGMAR1TDP1ALDH1A1CALM1
SCHEMBL7784549 0.80 CYP3A4 (0.52) MAPTL3MBTL1RAB9ALMNATSHR
SCHEMBL7793413 0.80 CYP3A4 (0.52) MAPTL3MBTL1RAB9ALMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE37087-E1 1-(4-ETHOXYPHENYL)-4-(4-FLUORO-3-PHENOXYPHENYL)-1 -TRIFLUOROMETHYLBUTANE OR 1-(4-ETHOXY-3-FLUOROPHENYL)-4-(3-PHENOXYPHENYL)-1-TRIFLUOROMETHYLBUTANE, FOR EXAMPLE; COMBATS INSECTS AND MITES SCHERING AKTIENGESELLSCHAFT (DE) 2001-03-06 US disclosed