Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASE1 | P07998 | 1/20 | 0.58 |
| ▸ | TK2 | O00142 | 2/20 | 0.47 |
| ▸ | TK1 | P04183 | 8/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7922859 | 1.00 | RNASE1 (0.58) | RNASE1TK2TK1 | |
| SCHEMBL25752670 | 0.91 | RNASE1 (0.59) | RNASE1TK2TK1 | |
| SCHEMBL16704351 | 0.90 | RNASE1 (0.71) | RNASE1TK2TK1 | |
| SCHEMBL1334032 | 0.90 | RNASE1 (0.71) | RNASE1TK2TK1 | |
| SCHEMBL1334035 | 0.90 | RNASE1 (0.71) | RNASE1TK2TK1 | |
| SCHEMBL16704350 | 0.87 | RNASE1 (0.55) | RNASE1TK2TK1 | |
| SCHEMBL3912309 | 0.84 | RNASE1 (0.54) | RNASE1TK2TK1 | |
| SCHEMBL29760775 | 0.84 | TOP2A (0.58) | RNASE1TK2TK1 | |
| SCHEMBL3912314 | 0.84 | RNASE1 (0.54) | RNASE1TK2TK1 | |
| SCHEMBL4578740 | 0.84 | TOP2A (0.58) | RNASE1TK2TK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214551-B1 | CONTACTING TEST SOLUTION CONTAINING NUCLEIC ACID WITH COMPOUND CONTAINING NUCLEOSIDE SEQUENCE WHEREIN NUCLEOSIDES ARE COVALENTLY BOUND THROUGH LINKING GROUP HAVING ADJACENT NITROGEN ATOMS FOR ASSAYING SEQUENCE-SPECIFIC NUCLEIC ACID | ISIS PHARMACEUTICALS, INC. | 2001-04-10 | — | — | US | disclosed |
| US-5792844-A | MIMIC AND/OR MODULATE THE ACTIVITY OF WILD-TYPE NUCLEIC ACIDS | ISIS PHARMACEUTICALS, INC. (US) | 1998-08-11 | — | — | US | disclosed |
| US-5618704-A | Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling | ISIS PHARMACUETICALS, INC. (US) | 1997-04-08 | — | — | US | disclosed |
| US-5489677-A | NUCLEASE RESISTANT OLIGONUCLEOTIDE ANALOGS | ISIS PHARMACEUTICALS, INC. (US) | 1996-02-06 | — | — | US | disclosed |
| WO-1994022893-A1 | OLIGONUCLEOSIDE LINKAGES CONTAINING ADJACENT NITROGEN ATOMS | ISIS PHARMACEUTICALS, INC. (US) | 1994-10-13 | — | — | WO | disclosed |
| WO-1994022894-A1 | BACKBONE MODIFIED OLIGONUCLEOTIDE ANALOGS AND PREPARATION THEREOF THROUGH RADICAL COUPLING | ISIS PHARMACEUTICALS, INC. (US) | 1994-10-13 | — | — | WO | disclosed |
| WO-1994022454-A1 | OLIGONUCLEOSIDE LINKAGES CONTAINING ADJACENT OXYGEN AND NITROGEN ATOMS | ISIS PHARMACEUTICALS, INC. (US) | 1994-10-13 | — | — | WO | disclosed |