Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.43 |
| ▸ | CASP3 | P42574 | 2/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.43 |
| ▸ | FABP7 | O15540 | 1/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8696511 | 0.84 | KMT2A (0.61) | KMT2AEPHX2CASP3FABP7FABP5 | |
| SCHEMBL8046428 | 0.81 | KMT2A (0.91) | KMT2AEPHX2HDAC3HDAC1HDAC2 | |
| SCHEMBL17599913 | 0.81 | KMT2A (0.91) | KMT2AEPHX2HDAC3HDAC1HDAC2 | |
| SCHEMBL7932753 | 0.81 | HDAC3 (0.47) | KMT2AEPHX2SOAT1HDAC3HDAC1 | |
| SCHEMBL7103716 | 0.81 | KMT2A (0.68) | KMT2AEPHX2CASP3FABP7FABP5 | |
| SCHEMBL178761 | 0.81 | KMT2A (1.00) | KMT2AEPHX2CASP3FABP7FABP5 | |
| SCHEMBL178759 | 0.81 | KMT2A (1.00) | KMT2AEPHX2CASP3FABP7FABP5 | |
| SCHEMBL178760 | 0.81 | KMT2A (1.00) | KMT2AEPHX2CASP3FABP7FABP5 | |
| SCHEMBL17746959 | 0.81 | KMT2A (1.00) | KMT2AEPHX2CASP3FABP7FABP5 | |
| SCHEMBL178758 | 0.81 | KMT2A (1.00) | KMT2AEPHX2CASP3FABP7FABP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |