Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7924319 | 0.81 | KMT2A (0.67) | HDAC3HDAC1KMT2AEPHX2HDAC4 | |
| SCHEMBL3235360 | 0.77 | HDAC3 (0.72) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL7929314 | 0.75 | HDAC3 (0.52) | HDAC3HDAC1KMT2AMAPTMAPK1 | |
| SCHEMBL22444728 | 0.73 | KMT2A (0.53) | KMT2AEPHX2FABP5 | |
| SCHEMBL28134899 | 0.73 | SOAT1 (0.47) | KMT2AEPHX2MAPK1SOAT1TSHR | |
| SCHEMBL22444664 | 0.72 | KMT2A (0.49) | KMT2AEPHX2FABP5 | |
| SCHEMBL7929328 | 0.70 | KCNQ4 (0.43) | HDAC3HDAC1MAPTMAPK1HDAC2 | |
| SCHEMBL28741462 | 0.70 | EPHX2 (0.41) | KMT2AEPHX2FABP5 | |
| SCHEMBL9588677 | 0.69 | EPHX2 (0.56) | KMT2AEPHX2MAPTFABP5 | |
| SCHEMBL2922505 | 0.69 | EPHX2 (0.49) | HDAC3HDAC1KMT2AEPHX2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |