Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13342872 | 0.85 | HTR1A (0.65) | ALDH1A1MAPTHTTHTR1AMEN1 | |
| SCHEMBL8106834 | 0.85 | HTR1A (0.65) | ALDH1A1MAPTHTTHTR1AMEN1 | |
| SCHEMBL20382528 | 0.85 | HTR1A (0.65) | ALDH1A1MAPTHTTHTR1AMEN1 | |
| SCHEMBL19042307 | 0.82 | GRIN2D (0.43) | ALDH1A1TP53MAPTTHRBHTT | |
| SCHEMBL7998333 | 0.82 | LTA4H (0.43) | ALDH1A1TP53MAPTTHRBHTT | |
| SCHEMBL23731957 | 0.80 | PSMB1 (0.40) | ALDH1A1TP53MAPTTHRBHTT | |
| SCHEMBL29204593 | 0.79 | HRH3 (0.62) | ALDH1A1MAPTTHRBPSMB1PSMB5 | |
| SCHEMBL23732090 | 0.79 | SLC6A2 (0.45) | ALDH1A1HTTHTR1AMEN1KMT2A | |
| SCHEMBL18070205 | 0.78 | HRH3 (0.49) | HTR1AHRH3LTA4H | |
| SCHEMBL10869155 | 0.78 | HRH3 (0.57) | HTR1AHRH3LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039256-A1 | 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2010-04-08 | — | — | WO | disclosed |