Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.62 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.62 |
| ▸ | CA1 | P00915 | 4/20 | 0.60 |
| ▸ | CA2 | P00918 | 4/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL130343 | 0.95 | KDM4E (0.68) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| Trifluoroacetic Acid SCHEMBL2650961 | 0.86 | KDM4E (0.57) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL9717434 | 0.86 | MAPK1 (0.71) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL6263089 | 0.85 | MAPK1 (0.72) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL8407980 | 0.84 | F10 (0.60) | CA1CA2MAPK1 | |
| SCHEMBL8435925 | 0.83 | MAPK1 (0.81) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL28757390 | 0.82 | MAPK1 (0.84) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL6258138 | 0.82 | MAPK1 (0.84) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL9344489 | 0.82 | KDM4E (0.68) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL5926408 | 0.81 | EPHX2 (0.63) | CA1CA2MAPK1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228985-B1 | COMPOUNDS THAT INHIBIT INTERACTION OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR WITH UROKINASE-TYPE PLASMINOGEN RECEPTOR; ANTITUMOR AGENTS; ANTIMETASTASIS AGENTS; ANTIARTHRITIC AGENTS FOR RHEUMATOID ARTHRITIS | SCHERING CORPORATION | 2001-05-08 | — | — | US | disclosed |