Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CDC25B | P30305 | 3/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | CDC25A | P30304 | 1/20 | 0.42 |
| ▸ | CDC25C | P30307 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1433197 | 0.88 | ALDH1A1 (0.53) | ALDH1A1HPGDKMT2ACDC25BMMP8 | |
| SCHEMBL28028637 | 0.87 | HPGD (0.49) | ALDH1A1HPGDMEN1KMT2ANPC1 | |
| SCHEMBL846623 | 0.84 | ALDH1A1 (0.49) | ALDH1A1HPGDKMT2ACDC25BMMP8 | |
| SCHEMBL20912990 | 0.82 | ALDH1A1 (0.47) | ALDH1A1HPGDKMT2ACDC25BMMP8 | |
| SCHEMBL9352212 | 0.81 | CTNNB1 (0.51) | CTNNB1ALDH1A1HPGDNPC1HTT | |
| SCHEMBL25156303 | 0.78 | KMT2A (0.52) | ALDH1A1HPGDMEN1KMT2ACDC25B | |
| SCHEMBL31360448 | 0.78 | KMT2A (0.52) | ALDH1A1HPGDMEN1KMT2ACDC25B | |
| SCHEMBL15203285 | 0.78 | KMT2A (0.52) | ALDH1A1HPGDMEN1KMT2ACDC25B | |
| SCHEMBL10412730 | 0.78 | ALDH1A1 (0.51) | ALDH1A1HPGDKMT2ACDC25BCDC25A | |
| SCHEMBL6908528 | 0.77 | MMP8 (0.64) | ALDH1A1MEN1KMT2ANPC1MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1252069-C | 2-aryl-naphthyridin-4-ones as antitumor agents | UNIV NORTH CAROLINA CHAPEL HILL (US) | 2006-04-19 | — | — | CN | disclosed |
| US-6229016-B1 | PYRIDOPYRIMIDINE DERIVATIVES AS CHEMICAL INTERMEDIATES; POLYMERIZATION INHIBITION OF TUBULIN | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2001-05-08 | — | — | US | disclosed |
| CN-1259947-A | 2-aryl-naphthyridin-4-ones as antitumor agents | UNIV NORTH CAROLINA CHAPEL HILL (US) | 2000-07-12 | — | — | CN | disclosed |
| US-6071930-A | FOR INHIBITION OF MITOSIS OR TUMOR GROWTH | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-06-06 | — | — | US | disclosed |
| EP-0971921-A1 | 2-ARYL-NAPHTHYRIDIN-4-ONES AS ANTITUMOR AGENTS | The University of North Carolina at Chapel Hill (US) | 2000-01-19 | — | — | EP | disclosed |
| US-5994367-A | PREVENT CELL MITOSIS; ANTICARCINOGENIC AGENTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-11-30 | — | — | US | disclosed |
| WO-1998039332-A1 | 2-ARYL-NAPHTHYRIDIN-4-ONES AS ANTITUMOR AGENTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1998-09-11 | — | — | WO | disclosed |