Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8732063 | 0.77 | SLC6A1 (0.45) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL3276106 | 0.77 | GSK3B (0.47) | GSK3BPOLB | |
| SCHEMBL7768683 | 0.69 | GSK3B (0.47) | GSK3BPOLB | |
| SCHEMBL23145052 | 0.68 | GSK3B (0.46) | GSK3BPOLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL22754316 | 0.68 | SMN1; SMN2 (0.49) | GSK3BPOLBPKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL10406650 | 0.67 | TBXAS1 (0.52) | — | |
| SCHEMBL10406649 | 0.67 | TBXAS1 (0.52) | — | |
| SCHEMBL9773473 | 0.66 | TBXAS1 (0.40) | — | |
| SCHEMBL9773468 | 0.66 | TBXAS1 (0.40) | — | |
| SCHEMBL21653995 | 0.66 | POLB (0.43) | GSK3BPOLBPKMSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174898-B1 | TREATING FILARIAE IN LYMPHATIC SYSTEM BY ADMINISTERING N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND ESTERS IN WHICH A SUBSTITUTED ALKYL CHAIN FORMS PART OF N-SUBSTITUENT AND SALTS | NOVO NORDISK A/S (DK) | 2001-01-16 | — | — | US | disclosed |
| EP-0374801-B1 | Novel N-sustituted azaheterocyclic carboxylic acids | NOVO NORDISK AS (DK) | 1997-03-19 | — | — | EP | disclosed |
| US-5214057-A | Used as analgesic, anxiolytic, antidepressant, hypnotic and for treating epilepsy and muscular disorder | NOVO NORDISK A/S (DK) | 1993-05-25 | — | — | US | disclosed |
| US-5071859-A | Analgesic, antianxiolytic, antiepileptic, antidepressant; gammaa-aminobutyric acid inhibitor | NOVO NORDISK A/S, A CORP. OF DENMARK (DK) | 1991-12-10 | — | — | US | disclosed |
| EP-0374801-A2 | Novel N-sustituted azaheterocyclic carboxylic acids | NOVO NORDISK A/S (DK) | 1990-06-27 | — | — | EP | disclosed |