Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 3/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3931548 | 0.76 | HRH1 (0.50) | ALOX5HRH1SLC6A4SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL7935046 | 0.72 | ALOX5 (0.35) | ALOX5HRH1SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL7938198 | 0.70 | SLC6A2 (0.39) | ALOX5HRH1SLC6A4SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL7932246 | 0.70 | HRH1 (0.44) | HRH1SLC6A4SLC6A2SLC6A3HTR1A | |
| Hydrochloric Acid SCHEMBL7934442 | 0.70 | HRH1 (0.37) | ALOX5HRH1SLC6A4SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL7938189 | 0.66 | SLC6A2 (0.32) | ALOX5SLC6A2SLC6A3 | |
| SCHEMBL22244223 | 0.65 | HRH1 (0.37) | ALOX5HRH1SLC6A4SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL7925591 | 0.65 | SMN1; SMN2 (0.38) | HRH1SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL7938098 | 0.64 | — | — | |
| SCHEMBL11547849 | 0.64 | PARP16 (0.34) | ALOX5HRH1SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6169152-B1 | COPOLYMER OF ETHYLENE AND A POLAR GROUP-CONTAINING CYCLIC OLEFIN COMPRISING ESTER- OR ANHYDRIDE MODIFIED NORBORNENE OR PERHYDRO-2,3-DIDEHYDRO-1,4:5,8-DIMETHANONAPHTHALENE MADE WITH CATALYST SUCH AS 1,5,9-TRIAZACYCLODODECANYLTITANIUM CHLORIDE | JSR CORPORATION (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0816387-A1 | Olefin-polymerizing catalyst | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1998-01-07 | — | — | EP | disclosed |