Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A3 known ✓ | Q01959 | 4/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7932276 | 0.78 | HRH1 (0.50) | HRH1LTA4HSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15974677 | 0.75 | SLC6A2 (0.51) | HRH1LTA4HSLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL7934463 | 0.73 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3SIGMAR1HTR3E | |
| SCHEMBL27889106 | 0.73 | HRH1 (0.40) | HRH1LTA4HSLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL7934421 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL7932341 | 0.71 | HRH1 (0.36) | HRH1LTA4HSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2214066 | 0.71 | HTR2C (0.42) | HRH1LTA4HSLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL7925664 | 0.70 | ALOX5 (0.38) | HRH1SLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL9286439 | 0.70 | PRCP (0.37) | HRH1LTA4HSLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL7934442 | 0.70 | HRH1 (0.37) | HRH1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6169152-B1 | COPOLYMER OF ETHYLENE AND A POLAR GROUP-CONTAINING CYCLIC OLEFIN COMPRISING ESTER- OR ANHYDRIDE MODIFIED NORBORNENE OR PERHYDRO-2,3-DIDEHYDRO-1,4:5,8-DIMETHANONAPHTHALENE MADE WITH CATALYST SUCH AS 1,5,9-TRIAZACYCLODODECANYLTITANIUM CHLORIDE | JSR CORPORATION (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0816387-A1 | Olefin-polymerizing catalyst | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1998-01-07 | — | — | EP | disclosed |