Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SLC26A4 | O43511 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1391022 | 0.88 | NPC1 (0.45) | NPC1MAPTTAS1R3TAS1R1RAB9A | |
| SCHEMBL7924664 | 0.88 | APP (0.42) | NPC1MAPTAPPRAB9AKMT2A | |
| SCHEMBL9827175 | 0.80 | CA12 (0.45) | TAS1R3TAS1R1KMT2AMEN1BLM | |
| SCHEMBL1390985 | 0.78 | KMT2A (0.44) | NPC1MAPTRAB9ATDP1KMT2A | |
| SCHEMBL1390573 | 0.77 | MAOA (0.60) | NPC1KMT2AMEN1MAOAMAOB | |
| SCHEMBL7924980 | 0.77 | MAOA (0.42) | TAS1R3TAS1R1KMT2ASLC26A4MEN1 | |
| SCHEMBL9826727 | 0.75 | TAS1R3 (0.56) | APPTAS1R3TAS1R1ALDH1A1HPGD | |
| SCHEMBL20559453 | 0.75 | TAS1R3 (0.56) | APPTAS1R3TAS1R1ALDH1A1HPGD | |
| SCHEMBL7921540 | 0.75 | MAOA (0.41) | TAS1R3TAS1R1KMT2ASLC26A4MEN1 | |
| SCHEMBL7921902 | 0.74 | HDAC8 (0.43) | TAS1R3TAS1R1KMT2AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010050445-A1 | BICYCLIC COMPOUND | 武田薬品工業株式会社 (JP) | 2010-05-06 | — | — | WO | disclosed |