Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SLC26A4 | O43511 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 5/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1390985 | 0.90 | KMT2A (0.44) | NPC1RAB9ASLC26A4KMT2ALMNA | |
| SCHEMBL7925702 | 0.88 | NPC1 (0.43) | APPNPC1RAB9ASLC26A4KMT2A | |
| SCHEMBL1391015 | 0.78 | MAOA (0.60) | NPC1KMT2AMEN1MAOBMAOA | |
| SCHEMBL7924980 | 0.78 | MAOA (0.42) | SLC26A4KMT2ALMNAMEN1BLM | |
| SCHEMBL1391022 | 0.76 | NPC1 (0.45) | NPC1RAB9AKMT2AMEN1BLM | |
| SCHEMBL7922363 | 0.76 | TAS1R3 (0.52) | APPKMT2AMEN1MAOBPTGES | |
| SCHEMBL7921540 | 0.76 | MAOA (0.41) | SLC26A4KMT2ALMNAMEN1BLM | |
| SCHEMBL7921902 | 0.75 | HDAC8 (0.43) | KMT2AHDAC6MAOBMAOA | |
| SCHEMBL1390592 | 0.75 | POLB (0.42) | NPC1RAB9AKMT2AMEN1BLM | |
| SCHEMBL1390663 | 0.74 | ALOX5 (0.50) | NPC1RAB9AKMT2ALMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010050445-A1 | BICYCLIC COMPOUND | 武田薬品工業株式会社 (JP) | 2010-05-06 | — | — | WO | disclosed |