Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 6/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | DHODH | Q02127 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1920755 | 0.92 | NPC1 (0.60) | NPC1RAB9AHPGDALOX15HSD17B10 | |
| SCHEMBL378949 | 0.90 | SMN1; SMN2 (0.62) | NPC1RAB9AHPGDALOX15HSD17B10 | |
| SCHEMBL657416 | 0.89 | KDM1A (0.62) | NPC1RAB9AHPGDPTGS2ALOX15 | |
| SCHEMBL1921386 | 0.86 | CLK1 (0.55) | NPC1RAB9APTGS2ALOX15HSD17B10 | |
| SCHEMBL1122280 | 0.85 | NPC1 (0.55) | EGFRNPC1RAB9APTGS2ALOX15 | |
| SCHEMBL1920761 | 0.85 | NPC1 (0.54) | EGFRNPC1RAB9AHPGDPTGS2 | |
| SCHEMBL21933258 | 0.83 | CYP19A1 (0.59) | NPC1RAB9AHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL15363908 | 0.82 | EGFR (0.56) | EGFRNPC1RAB9AHPGDALOX15 | |
| SCHEMBL7925274 | 0.82 | NPSR1 (0.55) | NPC1RAB9AHPGDALOX15HSD17B10 | |
| SCHEMBL3502973 | 0.82 | MEN1 (0.61) | NPC1RAB9APTGS2ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190177265-A1 | METHOD FOR COUPLING A FIRST COMPOUND TO A SECOND COMPOUND | DOW AGROSCIENCES LLC (US) | 2019-06-13 | — | — | US | disclosed |
| EP-2558446-B1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS | AC IMMUNE SA (CH) | 2019-06-12 | — | — | EP | disclosed |
| US-20170210695-A1 | METHOD FOR COUPLING A FIRST COMPOUND TO A SECOND COMPOUND | DOW AGROSCIENCES LLC | 2017-07-27 | — | — | US | disclosed |
| EP-2688870-B1 | HETEROCYCLIC AMINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-02-01 | — | — | EP | disclosed |
| US-20160158242-A1 | Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins | AC IMMUNE SA (CH) | 2016-06-09 | — | — | US | disclosed |
| US-20160158242-A1 | Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins | AC IMMUNE SA (CH) | 2016-06-09 | — | — | US | disclosed |
| WO-2016057770-A1 | METHOD FOR COUPLING A FLUOROSULFONATE COMPOUND WITH AN AMINE COMPOUND | DOW GLOBAL TECHNOLOGIES LLC (US) | 2016-04-14 | — | — | WO | disclosed |
| US-9221812-B2 | Compounds for the treatment of diseases associated with amyloid or amyloid-like proteins | AC IMMUNE SA (CH) | 2015-12-29 | — | — | US | disclosed |
| US-9221812-B2 | Compounds for the treatment of diseases associated with amyloid or amyloid-like proteins | AC IMMUNE SA (CH) | 2015-12-29 | — | — | US | disclosed |
| US-20110280808-A1 | Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins | AC IMMUNE, S.A. (CH) | 2011-11-17 | — | — | US | disclosed |
| US-20110280808-A1 | Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins | AC IMMUNE, S.A. (CH) | 2011-11-17 | — | — | US | disclosed |
| WO-2011128455-A1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS | AC IMMUNE S.A. (CH) | 2011-10-20 | — | — | WO | disclosed |
| US-6228547-B1 | CHARGE TRANSFER COMPOUNDS | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2001-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190177265-A1 | METHOD FOR COUPLING A FIRST COMPOUND TO A SECOND COMPOUND | PAICS, NUDT21, TIAL1 | EGFR 2530/4885NPC1 950/4885RAB9A 880/4885 |
| US-20170210695-A1 | METHOD FOR COUPLING A FIRST COMPOUND TO A SECOND COMPOUND | PAICS, NUDT21, TIAL1 | EGFR 2530/4885NPC1 950/4885RAB9A 880/4885 |
| US-20110280808-A1 | Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins | APP, PSEN1, PSEN2 | EGFR 3704/4885NPC1 430/4885RAB9A 2613/4885 |
| US-20160158242-A1 | Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins | APP, PSEN1, PSEN2 | EGFR 3704/4885NPC1 430/4885RAB9A 2613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.