Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | NPC1 | O15118 | 6/20 | 0.62 |
| ▸ | RAB9A | P51151 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.56 |
| ▸ | RELA | Q04206 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | CLK2 | P49760 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1920755 | 0.98 | NPC1 (0.60) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL1921386 | 0.92 | CLK1 (0.55) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL7926077 | 0.90 | EGFR (0.58) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL12128808 | 0.87 | NPC1 (0.60) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL11469590 | 0.87 | ALDH1A1 (0.62) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL24777901 | 0.86 | ADRA2A (0.61) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL1920761 | 0.86 | NPC1 (0.54) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL15363908 | 0.84 | EGFR (0.56) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL7925274 | 0.84 | NPSR1 (0.55) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL4133787 | 0.84 | LMNA (0.52) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1801105-B1 | Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions | CHEVRON ORONITE CO (US) | 2012-01-25 | — | — | EP | claimed |
| US-7285518-B2 | Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions | CHEVRON ORONITE COMPANY LLC (US) | 2007-10-23 | — | — | US | claimed |
| EP-1801105-A1 | Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions | Chevron Oronite Company LLC (US) | 2007-06-27 | — | — | EP | claimed |
| US-20070142245-A1 | Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions | CHEVRON ORONITE COMPANY LLC | 2007-06-21 | — | — | US | claimed |
| EP-2558446-B1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS | AC IMMUNE SA (CH) | 2019-06-12 | — | — | EP | disclosed |
| US-20160158242-A1 | Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins | AC IMMUNE SA (CH) | 2016-06-09 | — | — | US | disclosed |
| US-20160158242-A1 | Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins | AC IMMUNE SA (CH) | 2016-06-09 | — | — | US | disclosed |
| US-9221812-B2 | Compounds for the treatment of diseases associated with amyloid or amyloid-like proteins | AC IMMUNE SA (CH) | 2015-12-29 | — | — | US | disclosed |
| US-9221812-B2 | Compounds for the treatment of diseases associated with amyloid or amyloid-like proteins | AC IMMUNE SA (CH) | 2015-12-29 | — | — | US | disclosed |
| EP-1801105-B1 | Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions | CHEVRON ORONITE CO (US) | 2012-01-25 | — | — | EP | disclosed |
| EP-1801105-B1 | Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions | CHEVRON ORONITE CO (US) | 2012-01-25 | — | — | EP | disclosed |
| US-20110280808-A1 | Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins | AC IMMUNE, S.A. (CH) | 2011-11-17 | — | — | US | disclosed |
| US-7285518-B2 | Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions | CHEVRON ORONITE COMPANY LLC (US) | 2007-10-23 | — | — | US | disclosed |
| US-7285518-B2 | Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions | CHEVRON ORONITE COMPANY LLC (US) | 2007-10-23 | — | — | US | disclosed |
| US-7285518-B2 | Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions | CHEVRON ORONITE COMPANY LLC (US) | 2007-10-23 | — | — | US | disclosed |
| EP-1801105-A1 | Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions | Chevron Oronite Company LLC (US) | 2007-06-27 | — | — | EP | disclosed |
| EP-1801105-A1 | Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions | Chevron Oronite Company LLC (US) | 2007-06-27 | — | — | EP | disclosed |
| US-20070142245-A1 | Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions | CHEVRON ORONITE COMPANY LLC | 2007-06-21 | — | — | US | disclosed |
| US-20070142245-A1 | Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions | CHEVRON ORONITE COMPANY LLC | 2007-06-21 | — | — | US | disclosed |
| US-20070142245-A1 | Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions | CHEVRON ORONITE COMPANY LLC | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142245-A1 | Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions | ALOX12, ALOX15B, HRH1 | SMN1; SMN2 1759/4885MAPT 1361/4885NPC1 2776/4885 |
| US-20110280808-A1 | Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins | APP, PSEN1, PSEN2 | SMN1; SMN2 1899/4885MAPT 11/4885NPC1 430/4885 |
| US-20160158242-A1 | Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins | APP, PSEN1, PSEN2 | SMN1; SMN2 1899/4885MAPT 11/4885NPC1 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.