SCHEMBL1921386

SCHEMBL1921386

c1cc(-c2ccc(Nc3ccc4c(c3)OCO4)cc2)ccc1Nc1ccc2c(c1)OCO2

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CLK1 P49759 1/20 0.55
CLK2 P49760 1/20 0.55
DYRK1A Q13627 1/20 0.55
CLK4 Q9HAZ1 1/20 0.55
DYRK1B Q9Y463 1/20 0.55
MAPT P10636 7/20 0.55
SMN1; SMN2 Q16637 6/20 0.55
NPC1 O15118 6/20 0.55
RAB9A P51151 6/20 0.55
ALDH1A1 P00352 5/20 0.55
MEN1 O00255 3/20 0.55
KMT2A Q03164 3/20 0.55
GAA P10253 2/20 0.55
POLB P06746 2/20 0.55
KIF11 P52732 1/20 0.54
LMNA P02545 1/20 0.51
HSD17B10 Q99714 2/20 0.51
TSHR P16473 1/20 0.51
PTGS2 P35354 2/20 0.50
NFKB1 P19838 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1920755 0.94 NPC1 (0.60) CLK1CLK2DYRK1ACLK4DYRK1B
SCHEMBL378949 0.92 SMN1; SMN2 (0.62) CLK1CLK2DYRK1ACLK4DYRK1B
SCHEMBL7926077 0.86 EGFR (0.58) CLK4MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL11469590 0.83 ALDH1A1 (0.62) CLK1CLK2DYRK1ACLK4DYRK1B
SCHEMBL12128808 0.79 NPC1 (0.60) MAPTSMN1; SMN2NPC1RAB9AALDH1A1
SCHEMBL24777901 0.79 ADRA2A (0.61) MAPTSMN1; SMN2NPC1RAB9AALDH1A1
SCHEMBL1920761 0.78 NPC1 (0.54) MAPTSMN1; SMN2NPC1RAB9AALDH1A1
SCHEMBL7925274 0.77 NPSR1 (0.55) MAPTSMN1; SMN2NPC1RAB9AALDH1A1
SCHEMBL15363908 0.77 EGFR (0.56) MAPTSMN1; SMN2NPC1RAB9AALDH1A1
SCHEMBL4133787 0.77 LMNA (0.52) CLK1CLK2DYRK1ACLK4DYRK1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1528074-B1 NOVEL TRIARYLAMINE POLYMER, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF TOSOH CORP (JP) 2014-03-26 EP disclosed
EP-2327739-A1 Novel triarylamine polymer, process for its production and its use TOSOH CORPORATION (JP) 2011-06-01 EP disclosed
US-7608680-B2 Triarylamine polymer, process for producing the same, and use thereof TOSOH CORPORATION (JP) 2009-10-27 US disclosed
US-20060241278-A1 Novel triarylamine polymer, process for producing the same, and use thereof TOSOH CORPORATION (JP) 2006-10-26 US disclosed
US-20060017040-A9 Novel triarylamine polymer, process for producing the same, and use thereof SUZUKI TAKAO 2006-01-26 US disclosed
EP-1528074-A1 NOVEL TRIARYLAMINE POLYMER, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF Tosoh Corporation (JP) 2005-05-04 EP disclosed
US-20040262574-A1 Novel triarylamine polymer, process for producing the same, and use thereof TOSOH CORPORATION (JP) 2004-12-30 US disclosed