Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7933100 | 0.83 | KDM1A (0.33) | KDM1AALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL7936601 | 0.82 | SLC6A4 (0.33) | KDM1ASLC6A4DRD2ALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL7933117 | 0.81 | ALOX5 (0.35) | KDM1AALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL7936175 | 0.77 | KDM1A (0.31) | KDM1ASLC6A4DRD2ALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL8603782 | 0.73 | SLC6A4 (0.34) | KDM1ASLC6A4DRD2ALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL8604890 | 0.73 | SLC6A4 (0.36) | KDM1ASLC6A4DRD2ALDH1A1HTR2C | |
| Hydrochloric Acid SCHEMBL5604466 | 0.72 | SLC6A4 (0.33) | KDM1ASLC6A4DRD2ALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL5146591 | 0.70 | SLC6A4 (0.34) | ALOX15SLC6A4DRD2ALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL7584293 | 0.70 | SLC6A4 (0.34) | KDM1ASLC6A4DRD2ALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL6371618 | 0.70 | SLC6A4 (0.34) | ALOX15SLC6A4DRD2ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184402-B1 | RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES | CHISSO CORPORATION (JP) | 2001-02-06 | — | — | US | disclosed |