Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 9/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.42 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.42 |
| ▸ | EBP | Q15125 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7778580 | 0.85 | LTA4H (0.53) | LTA4HPTGS2POLBMAPTHRH3 | |
| SCHEMBL7918786 | 0.82 | LTA4H (0.47) | LTA4HPTGS2KCNH2HRH3KDM4E | |
| SCHEMBL1359779 | 0.78 | ESR1 (0.51) | ESR1 | |
| SCHEMBL1359072 | 0.78 | ESR1 (0.51) | ESR1 | |
| Hydrochloric Acid SCHEMBL2183048 | 0.78 | ESR1 (0.51) | ESR1 | |
| SCHEMBL7212312 | 0.77 | PSMB1 (0.49) | LTA4HPTGS2KCNH2HRH3KDM4E | |
| SCHEMBL7466056 | 0.76 | LTA4H (0.61) | LTA4HKCNH2HRH3KDM4E | |
| SCHEMBL7108553 | 0.75 | KDM4E (0.49) | LTA4HPTGS2POLBMAPTESR1 | |
| SCHEMBL1358434 | 0.73 | ESR1 (0.51) | LTA4HESR1PSMB1PSMB5PSMB2 | |
| SCHEMBL5418196 | 0.73 | ESR1 (0.49) | LTA4HESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729956-B1 | Benzothiophene compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2001-10-31 | — | — | EP | disclosed |
| EP-1113013-A1 | Benzothiophene compounds, intermediates, compositions and methods | Eli Lilly & Company (US) | 2001-07-04 | — | — | EP | disclosed |
| US-5977093-A | INHIBITING ESTROGEN-DEPENDENT CANCER | ELI LILLY AND COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0729956-A1 | Benzothiophene compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |