Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7173163 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL7935735 | 0.76 | HPRT1 (0.33) | HPRT1 | |
| SCHEMBL7935709 | 0.71 | HPRT1 (0.35) | HPRT1TDP1KDM4E | |
| SCHEMBL7926905 | 0.64 | HPRT1 (0.36) | HPRT1TDP1KDM4E | |
| SCHEMBL8740444 | 0.58 | HPRT1 (0.50) | HPRT1TDP1KDM4E | |
| SCHEMBL10877850 | 0.58 | HPRT1 (0.45) | HPRT1TDP1KDM4E | |
| Chrysene SCHEMBL9786466 | 0.58 | HPRT1 (1.00) | HPRT1TDP1 | |
| Chrysene SCHEMBL384031 | 0.58 | HPRT1 (1.00) | HPRT1TDP1 | |
| Chrysene SCHEMBL27115 | 0.58 | HPRT1 (1.00) | HPRT1TDP1 | |
| SCHEMBL31177955 | 0.58 | HPRT1 (1.00) | HPRT1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329486-B1 | PHYSICAL PROPERTIES | THE DOW CHEMICAL COMPANY | 2001-12-11 | — | — | US | disclosed |
| US-6323294-B1 | CONTACTING C.SUB.2-100,000 OLEFIN/S UNDER POLYMERIZATION CONDITIONS WITH CATALYST SYSTEM COMPRISING METAL COMPLEX AND ACTIVATING COCATALYST OR REACTION PRODUCT OF METAL COMPLEX AND COCATALYST TO FORM ADDITION POLYMER | THE DOW CHEMICAL COMPANY | 2001-11-27 | — | — | US | disclosed |