Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7926903 | 0.76 | HPRT1 (0.33) | HPRT1 | |
| SCHEMBL7926980 | 0.73 | HPRT1 (0.35) | HPRT1MEN1USP2ALDH1A1LMNA | |
| SCHEMBL7926994 | 0.71 | HPRT1 (0.35) | HPRT1MEN1USP2ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL7257433 | 0.63 | — | — | |
| Hydrochloric Acid SCHEMBL7173163 | 0.62 | — | — | |
| SCHEMBL8740444 | 0.58 | HPRT1 (0.50) | HPRT1ALDH1A1CYP1A2HPGDHIF1A | |
| Chrysene SCHEMBL9786466 | 0.58 | HPRT1 (1.00) | HPRT1MEN1USP2ALDH1A1LMNA | |
| SCHEMBL25510 | 0.58 | HPRT1 (1.00) | HPRT1MEN1USP2ALDH1A1LMNA | |
| Chrysene SCHEMBL384031 | 0.58 | HPRT1 (1.00) | HPRT1MEN1USP2ALDH1A1LMNA | |
| Chrysene SCHEMBL27115 | 0.58 | HPRT1 (1.00) | HPRT1MEN1USP2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329486-B1 | PHYSICAL PROPERTIES | THE DOW CHEMICAL COMPANY | 2001-12-11 | — | — | US | disclosed |
| US-6323294-B1 | CONTACTING C.SUB.2-100,000 OLEFIN/S UNDER POLYMERIZATION CONDITIONS WITH CATALYST SYSTEM COMPRISING METAL COMPLEX AND ACTIVATING COCATALYST OR REACTION PRODUCT OF METAL COMPLEX AND COCATALYST TO FORM ADDITION POLYMER | THE DOW CHEMICAL COMPANY | 2001-11-27 | — | — | US | disclosed |
| EP-1017701-A1 | CYCLOPENTAPHENANTHRENEYL METAL COMPLEXES AND POLYMERIZATION PROCESS | THE DOW CHEMICAL COMPANY (US) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999014221-A1 | CYCLOPENTAPHENANTHRENEYL METAL COMPLEXES AND POLYMERIZATION PROCESS | THE DOW CHEMICAL COMPANY (US) | 1999-03-25 | — | — | WO | disclosed |