Iodide

Iodide

SCHEMBL7927461

CCCC(=O)Nc1ccccc1.I

nearest known ligand 0.83

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG

The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.83
MAPT P10636 3/20 0.83
HPGD P15428 1/20 0.83
SMN1; SMN2 Q16637 2/20 0.70
HTT P42858 2/20 0.70
NPC1 O15118 2/20 0.70
RAB9A P51151 2/20 0.70
TP53 P04637 1/20 0.69
CYP2C19 P33261 1/20 0.69
RECQL P46063 1/20 0.69
ALOX5 P09917 1/20 0.65
L3MBTL1 Q9Y468 2/20 0.61
ICMT O60725 1/20 0.59
ALB P02768 1/20 0.59
HDAC3 O15379 1/20 0.59
HDAC1 Q13547 1/20 0.59
HDAC2 Q92769 1/20 0.59
SOAT2 O75908 1/20 0.59
SOAT1 P35610 1/20 0.59
GAA P10253 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9888 0.98 ALDH1A1 (0.86) ALDH1A1MAPTHPGDSMN1; SMN2HTT
SCHEMBL11658250 0.96 ALDH1A1 (0.83) ALDH1A1MAPTHPGDSMN1; SMN2HTT
Fluoride SCHEMBL27839088 0.96 ALDH1A1 (0.83) ALDH1A1MAPTHPGDSMN1; SMN2HTT
Hydrochloric Acid SCHEMBL23062930 0.96 ALDH1A1 (0.83) ALDH1A1MAPTHPGDSMN1; SMN2HTT
Bromide SCHEMBL28587932 0.96 ALDH1A1 (0.83) ALDH1A1MAPTHPGDSMN1; SMN2HTT
Phenol SCHEMBL28178784 0.91 MAPT (0.75) ALDH1A1MAPTHPGDSMN1; SMN2HTT
SCHEMBL9479666 0.91 MAPT (1.00) ALDH1A1MAPTHPGDSMN1; SMN2HTT
SCHEMBL27874246 0.88 ALDH1A1 (0.71) ALDH1A1MAPTHPGDSMN1; SMN2HTT
SCHEMBL2183716 0.86 ALDH1A1 (0.76) ALDH1A1MAPTHPGDSMN1; SMN2ICMT
SCHEMBL3342586 0.85 L3MBTL1 (0.80) ALDH1A1MAPTHPGDSMN1; SMN2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001017992-A1 INHIBITORS OF PRENYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 2001-03-15 WO disclosed