Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Malonic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.64 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.35 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.35 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KDM6B | O15054 | 1/20 | 0.30 |
| ▸ | KDM5C | P41229 | 1/20 | 0.30 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.30 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malonic Acid SCHEMBL30678826 | 0.93 | LDHA (0.64) | LDHASRRLMNAEGLN1ALKBH5 | |
| Malonic Acid SCHEMBL30678825 | 0.93 | LDHA (0.64) | LDHASRRLMNAEGLN1ALKBH5 | |
| Malonic Acid SCHEMBL16390546 | 0.93 | LDHA (0.75) | LDHASRRLMNAEGLN1ALKBH5 | |
| Malonic Acid SCHEMBL15709489 | 0.93 | LDHA (0.75) | LDHASRRLMNAEGLN1ALKBH5 | |
| Malonic Acid SCHEMBL28591776 | 0.89 | LDHA (0.69) | LDHASRRLMNAEGLN1ALKBH5 | |
| Malonic Acid SCHEMBL19833892 | 0.89 | LDHA (0.69) | LDHASRRLMNAEGLN1ALKBH5 | |
| Malonic Acid SCHEMBL29046198 | 0.89 | LDHA (0.69) | LDHASRRLMNAEGLN1ALKBH5 | |
| Malonic Acid SCHEMBL28554209 | 0.89 | LDHA (0.69) | LDHASRRLMNAEGLN1ALKBH5 | |
| Malonic Acid SCHEMBL15992135 | 0.89 | LDHA (0.69) | LDHASRRLMNAEGLN1ALKBH5 | |
| Malonic Acid SCHEMBL27963974 | 0.87 | LDHA (0.56) | LDHASRRLMNAEGLN1ALKBH5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010033964-A1 | Alkylspiroborate salts for use in electrochemical cells | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG | 2001-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010033964-A1 | Alkylspiroborate salts for use in electrochemical cells | ABCB7, SLC8B1, FOSB | LDHA 1390/4885SRR 1184/4885LMNA 3132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.