FOSB

Protein FosB

188 patent compounds predicted against FOSB, 134 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2117317	1.00	1/20
SCHEMBL13726132	0.71	1/20
SCHEMBL2116061	0.70	1/20
SCHEMBL13724800	0.69	1/20
SCHEMBL13725202	0.68	1/20
SCHEMBL2804418	0.68	1/20
SCHEMBL14680373	0.68	1/20
SCHEMBL14758490	0.68	1/20
SCHEMBL13725690	0.67	1/20
SCHEMBL10077001	0.66	1/20
SCHEMBL13726071	0.65	1/20
SCHEMBL13726075	0.65	1/20
SCHEMBL2117400	0.65	1/20
SCHEMBL13856742	0.65	1/20
SCHEMBL23949485	0.64	1/20
SCHEMBL13725582	0.63	1/20
SCHEMBL13726141	0.63	1/20
SCHEMBL13856221	0.63	1/20
SCHEMBL13725212	0.62	1/20
SCHEMBL13056428	0.62	1/20

Germline variants in FOSB on Sugi Variant → ClinVar classifications, population frequency, and predictor agreement (AlphaMissense, SaProt, REVEL) Full FOSB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

Clinical trials — most relevant to FOSB by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cyclical Neuroactive Steroid Changes, Arousal, and Proximal Suicide Risk: An Experimental Approach	PHASE4	COMPLETED
Preoperative Ketamine Has no Preemptive Analgesic Effect in Patients Undergoing Colon Surgery.	PHASE4	COMPLETED
Effects of Repetitive Transcranial Magnetic Stimulation in the Treatment of Phantom Limb Pain in Landmine Victims: ANTARES	PHASE3	COMPLETED
Bone Graft Cultivation by Periosteal Elevation	PHASE3	UNKNOWN
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit	PHASE2/PHASE3	WITHDRAWN
miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment Outcome	PHASE2	COMPLETED
Rapid Antidepressant Effects of Yohimbine in Major Depression	PHASE2	COMPLETED
Evaluation of Tolerance, Suckling and Food Intake After Repeated Nasals Administrations of Oxytocin in PWS Infants	PHASE1/PHASE2	COMPLETED
Oxytocin for Oxidative Stress and Inflammation	PHASE2	COMPLETED
Lidocaine Infusion as a Treatment for Cocaine Relapse and Craving	PHASE2	COMPLETED
A Broad Multi-histology Phase II Study of the Multi-Kinase Inhibitor R935788 (Fostamatinib Disodium) in Advanced Colorectal, Non-small Cell Lung, Head and Neck Hepatocellular and Renal Cell Carcinomas, and Pheochromocytoma and Thyroid Tumors (Multi-H...	PHASE2	COMPLETED
The Relationship Between The Differential Expression Of FosB Protein In Laryngeal Cancer Tissues And Clinical Prognosis	nan	NOT_YET_RECRUITING
Effect of Different Therapeutic Strategies on Regulatory T Cells in Kidney Transplantation	nan	COMPLETED
Satiety Evaluation of Mature Okra Flour-incorporated Biscuit	nan	RECRUITING
Brain Tissue Integrity and Autonomic Function Alterations in Childhood OSA and ADHD, and After Adenotonsillectomy.	nan	UNKNOWN
Implications of Circadian Variation of Human Endocannabinoid Levels on Obesity Risk	nan	WITHDRAWN
Inflammatory Markers as Predictors of the Efficacy of Electroconvulsive Therapy (ECT) in Major Depression Patients	nan	COMPLETED
Bone Resorption, Osteoclastogenesis and Adalimumab	nan	COMPLETED
Neuroimaging Memories of Fear and Safety in the Human Brain	nan	UNKNOWN
IGF and Other Neurotrophic Factors in Patients With Dementia	nan	COMPLETED
The Phosphodiesterase-3 Inhibitor Cilostazol as an Adjunctive to Antidepressants in Patients With Major Depressive Disorder.	nan	COMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
Low Intensity Ultrasound Neuromodulation of Repetitive Negative Thinking In Depression	nan	COMPLETED
Effect of Gabapentin on GABA Concentration and Emotional Processing	nan	COMPLETED
MMP Polymorphisms and Acute Coronary Syndromes	nan	COMPLETED
Personalizing Preterm Neonatal Transfusions With Fetal Hemoglobin-Enriched Cord Blood	nan	NOT_YET_RECRUITING
Evaluation of the Effect of Alpha Lipoic Acid on Radiation Induced Dermatitis in Breast Cancer Patients	nan	RECRUITING
Study for the Multidimensional Analyses of Resistance and Toxicity to Immune- and Targeted-therapies.	nan	UNKNOWN
Comparing Outcomes of Theta Burst Stimulation in Depression Using Advanced PET Imaging	nan	NOT_YET_RECRUITING
Endophenotyping With Functional Magnetic Resonance Imaging (fMRI)	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a FOSB binder may also engage these)

Protein	Name	Similarity
D3ZLB7	—	1.000	D3ZLB7 →
P13346	—	1.000	P13346 →
Q9TUB3	—	1.000	Q9TUB3 →
P23050	—	1.000	P23050 →
O88479	—	0.997	O88479 →
O97930	—	0.996	O97930 →
P12841	—	0.996	P12841 →
Q8HZP6	—	0.995	Q8HZP6 →
P10158	—	0.995	P10158 →
P48755	—	0.994	P48755 →
Q56TN0	—	0.994	Q56TN0 →
P15407	—	0.994	P15407 →
FOS	Protein c-Fos	0.993	landscape →
O77628	—	0.993	O77628 →
P01102	—	0.993	P01102 →
Q9Z2Q8	—	0.992	Q9Z2Q8 →
P11939	—	0.991	P11939 →
P01101	—	0.991	P01101 →
P29176	—	0.990	P29176 →
Q56TT7	—	0.989	Q56TT7 →
A2A9T0	—	0.986	A2A9T0 →
Q91496	—	0.986	Q91496 →
P53450	—	0.985	P53450 →
P24793	—	0.985	P24793 →
O02761	—	0.983	O02761 →
Q66HA2	—	0.983	Q66HA2 →
P79702	—	0.983	P79702 →
P98180	—	0.983	P98180 →
Q9Z125	—	0.983	Q9Z125 →
Q64210	—	0.982	Q64210 →