Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PYGL | P06737 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7932806 | 0.88 | MAPT (0.47) | PKMMAPTNPC1SMN1; SMN2KDM4E | |
| SCHEMBL7929624 | 0.75 | NR4A2 (0.44) | TP53MAPTPOLB | |
| SCHEMBL3099561 | 0.73 | RAB9A (0.62) | TP53HPGDMAPTNPC1SMN1; SMN2 | |
| SCHEMBL1706973 | 0.73 | MEN1 (0.62) | TP53PKMMAPTNPC1SMN1; SMN2 | |
| SCHEMBL10126508 | 0.71 | NPC1 (0.67) | TP53PKMMAPTNPC1SMN1; SMN2 | |
| SCHEMBL7930108 | 0.71 | KMT2A (0.57) | TP53NPC1LMNARAB9APOLB | |
| SCHEMBL1645411 | 0.70 | MEN1 (0.58) | TP53PKMMAPTSMN1; SMN2HTT | |
| SCHEMBL4640437 | 0.70 | MAPT (0.54) | PKMMAPTNPC1SMN1; SMN2HTT | |
| SCHEMBL11676127 | 0.69 | KMT2A (0.69) | TP53HPGDMAPTNPC1SMN1; SMN2 | |
| SCHEMBL7566341 | 0.69 | MAPT (0.66) | TP53HPGDMAPTNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228868-B1 | ANTICARCINOGENIC AND ANTITUMOR AGENTS | ABBOTT LABORATORIES | 2001-05-08 | — | — | US | disclosed |