Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7928025 | 0.87 | SMPD1 (0.56) | KMT2ASMPD1ROCK2ROCK1MEN1 | |
| SCHEMBL8910176 | 0.85 | TDP1 (0.53) | KMT2ATP53TDP1MAPK1SMPD1 | |
| SCHEMBL11818791 | 0.84 | KMT2A (0.52) | KMT2ATP53MAPK1MEN1POLB | |
| SCHEMBL7930156 | 0.83 | HPGD (0.57) | KMT2AMAPK1MEN1NPC1RAB9A | |
| SCHEMBL7927749 | 0.80 | ALDH1A1 (0.57) | KMT2ATDP1ROCK2ROCK1MEN1 | |
| SCHEMBL3132145 | 0.79 | TDP1 (0.64) | KMT2ATP53TDP1MAPK1SMPD1 | |
| SCHEMBL7920931 | 0.79 | TP53 (0.42) | TP53ROCK2ROCK1 | |
| SCHEMBL7929603 | 0.79 | SMYD3 (0.45) | TP53ROCK2ROCK1POLBLMNA | |
| SCHEMBL11150888 | 0.77 | TDP1 (0.58) | KMT2ATP53TDP1MAPK1SMPD1 | |
| Hydrochloric Acid SCHEMBL9638801 | 0.77 | TDP1 (0.58) | KMT2ATP53TDP1MAPK1SMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228868-B1 | ANTICARCINOGENIC AND ANTITUMOR AGENTS | ABBOTT LABORATORIES | 2001-05-08 | — | — | US | disclosed |