SCHEMBL7928381

SCHEMBL7928381

COC(=O)c1ccc(C#CC(O)c2cc(C(C)(C)C)c(OCOCC[Si](C)(C)C)c(C(C)(C)C)c2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.37
KDM4E B2RXH2 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2C9 P11712 1/20 0.37
HPGD P15428 1/20 0.37
TSHR P16473 1/20 0.37
CYP2C19 P33261 1/20 0.37
HSD17B10 Q99714 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
MAPT P10636 3/20 0.36
POLB P06746 1/20 0.34
RAB9A P51151 1/20 0.34
PTPN11 Q06124 1/20 0.34
EGFR P00533 1/20 0.34
TP53 P04637 1/20 0.33
MDM2 Q00987 1/20 0.33
ACACB O00763 1/20 0.32
ADORA3 P0DMS8 1/20 0.32
ADORA2A P29274 1/20 0.32
ADORA1 P30542 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7751245 0.91 RARG (0.38) TSHRHSD17B10TP53MDM2ACACB
SCHEMBL7928363 0.88 CA12 (0.33) PTPN11TP53MAPK1
SCHEMBL7751141 0.82 EGLN1 (0.32)
SCHEMBL7753389 0.80
SCHEMBL7751119 0.78
SCHEMBL7713192 0.77 THRA (0.41) ALDH1A1KDM4ECYP1A2CYP2C9HPGD
SCHEMBL7709247 0.76 RARA (0.43) ALDH1A1KDM4ECYP1A2CYP2C9HPGD
SCHEMBL7715138 0.76 THRA (0.48) ALDH1A1KDM4EHPGDMAPK1
SCHEMBL28480511 0.73 MAPT (0.63) ALDH1A1KDM4EHPGDTDP1MAPT
SCHEMBL8725371 0.70 MAPT (0.40) ALDH1A1KDM4EHPGDHSD17B10TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6313162-B1 FOR USE IN HUMAN OR VETERINARY MEDICINE SUCH AS DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR AND OPHHALMOLOGICAL DISORDERS; AND IN COSMETICS CENTRE INTERNATIONAL DE RECHERCHE DERMATOLOGIQUES GALDERMA (C.I.R.D.) GALDERMA (FR) 2001-11-06 US disclosed
US-6046220-A ADMINISTERING TO THE PATIENT A PROPYNYL OR DIENYL BIAROMATIC COMPOUND TO TREAT A SKIN DISORDER, INFLAMMATORY CONDITIONS, VISION DEFECTS, ALOPECIA, CARDIOVASCULAR DISORDER, CANCER OR PRECANCER AND INSULIN DEPENDANT DIABETES CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2000-04-04 US disclosed