Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 8/20 | 0.64 |
| ▸ | GRM3 | Q14832 | 3/20 | 0.64 |
| ▸ | GRM5 | P41594 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.64 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.52 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quisqualate SCHEMBL3674132 | 0.80 | CYP1A2 (1.00) | FOLH1GRM3GRM5KDM4EMEN1 | |
| Quisqualate SCHEMBL136819 | 0.80 | CYP1A2 (1.00) | FOLH1GRM3GRM5KDM4EMEN1 | |
| Quisqualate SCHEMBL27790631 | 0.79 | CYP1A2 (0.97) | FOLH1GRM3GRM5KDM4EMEN1 | |
| SCHEMBL16528808 | 0.71 | FOLH1 (1.00) | FOLH1GRM3NAALAD2 | |
| SCHEMBL383173 | 0.71 | FOLH1 (1.00) | FOLH1GRM3NAALAD2 | |
| SCHEMBL16528703 | 0.71 | FOLH1 (1.00) | FOLH1GRM3NAALAD2 | |
| Quisqualate SCHEMBL15528499 | 0.71 | CYP1A2 (0.64) | FOLH1GRM3GRM5KDM4EMEN1 | |
| SCHEMBL31532299 | 0.70 | GRM5 (1.00) | FOLH1GRM3GRM5KDM4EMEN1 | |
| Benzene SCHEMBL8056005 | 0.69 | FOLH1 (0.92) | FOLH1GRM3NAALAD2 | |
| SCHEMBL15278193 | 0.64 | FOLH1 (1.00) | FOLH1GRM3NAALAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994707-A4 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARM INC (US) | 2001-11-14 | — | — | EP | disclosed |
| EP-0994707-A1 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-26 | — | — | EP | disclosed |
| EP-0954295-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-11-10 | — | — | EP | disclosed |
| WO-1998053812-A1 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1998-12-03 | — | — | WO | disclosed |
| WO-1997048409-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | disclosed |