Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 4/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.35 |
| ▸ | ACP3 | P15309 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5054489 | 0.85 | CETP (0.40) | CETPCNR2PPARASMN1; SMN2 | |
| SCHEMBL5058042 | 0.84 | APAF1 (0.40) | MMEACP3APAF1MEN1ALDH1A1 | |
| SCHEMBL5057857 | 0.83 | TBXAS1 (0.43) | SMN1; SMN2 | |
| SCHEMBL7928562 | 0.82 | CYSLTR2 (0.39) | POLBCETPCNR2MAPK1SMN1; SMN2 | |
| SCHEMBL7928565 | 0.81 | POLB (0.39) | POLBCETPCNR2HSD17B10MME | |
| SCHEMBL5057881 | 0.81 | ACP3 (0.41) | CETPCNR2ACP3KMT2A | |
| SCHEMBL7929239 | 0.78 | CETP (0.42) | CETPCNR2HSD17B10MMEECE1 | |
| SCHEMBL5054324 | 0.77 | ALDH1A1 (0.41) | ACP3APAF1ALDH1A1 | |
| SCHEMBL5060648 | 0.76 | CETP (0.46) | CETPCNR2HSD17B10MEN1KMT2A | |
| SCHEMBL5054814 | 0.75 | CETP (0.38) | CETPCNR2MEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994707-A4 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARM INC (US) | 2001-11-14 | — | — | EP | claimed |
| EP-0994707-A1 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-26 | — | — | EP | claimed |
| WO-1998053812-A1 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1998-12-03 | — | — | WO | claimed |