Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | BMP1 | P13497 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7815506 | 1.00 | BCHE (0.37) | BCHERENMAPTKMT2ACTSS | |
| SCHEMBL6943422 | 0.99 | BCHE (0.39) | BCHERENMAPTKMT2ACTSS | |
| SCHEMBL7764173 | 0.99 | BCHE (0.39) | BCHERENMAPTKMT2ACTSS | |
| SCHEMBL6943418 | 0.99 | BCHE (0.39) | BCHERENMAPTKMT2ACTSS | |
| SCHEMBL7764176 | 0.99 | BCHE (0.39) | BCHERENMAPTKMT2ACTSS | |
| SCHEMBL6986468 | 0.95 | BCHE (0.38) | BCHERENCTSSCTSKSMN1; SMN2 | |
| SCHEMBL6987806 | 0.83 | BCHE (0.37) | BCHERENCTSSCTSKMMP2 | |
| SCHEMBL6939989 | 0.82 | BCHE (0.39) | BCHERENCTSSCTSKMMP2 | |
| SCHEMBL6946023 | 0.81 | CTSK (0.33) | RENKMT2ACTSKSMN1; SMN2 | |
| SCHEMBL6945400 | 0.81 | CTSK (0.33) | RENKMT2ACTSKSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |