Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | CCR2 | P41597 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945400 | 1.00 | CTSK (0.33) | CTSKKMT2ARENPIK3CDCNR2 | |
| SCHEMBL7928707 | 0.81 | BCHE (0.37) | CTSKKMT2ARENSMN1; SMN2 | |
| SCHEMBL7815506 | 0.81 | BCHE (0.37) | CTSKKMT2ARENSMN1; SMN2 | |
| SCHEMBL7764173 | 0.80 | BCHE (0.39) | CTSKKMT2ARENSMN1; SMN2 | |
| SCHEMBL6943422 | 0.80 | BCHE (0.39) | CTSKKMT2ARENSMN1; SMN2 | |
| SCHEMBL6943418 | 0.80 | BCHE (0.39) | CTSKKMT2ARENSMN1; SMN2 | |
| SCHEMBL7764176 | 0.80 | BCHE (0.39) | CTSKKMT2ARENSMN1; SMN2 | |
| SCHEMBL6986468 | 0.79 | BCHE (0.38) | CTSKRENSMN1; SMN2 | |
| SCHEMBL15015766 | 0.78 | CTSL (0.39) | CTSKKMT2ARECQL | |
| SCHEMBL7762836 | 0.78 | CTSL (0.39) | CTSKKMT2ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |