Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 5/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | CTSG | P08311 | 1/20 | 0.32 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7928430 | 0.86 | CETP (0.36) | CETPCSNK1ECNR2PRSS1CTSG | |
| SCHEMBL7931915 | 0.75 | CETP (0.41) | CETPCNR2PRSS1CTSGCTRB1 | |
| SCHEMBL5053060 | 0.74 | CETP (0.39) | CETPCSNK1ECNR2ENPP2DGAT2 | |
| SCHEMBL5051174 | 0.73 | CETP (0.38) | CETPCSNK1ECNR2ENPP2DGAT2 | |
| SCHEMBL5053293 | 0.73 | CETP (0.41) | CETPCSNK1ECNR2ENPP2S1PR4 | |
| SCHEMBL5053184 | 0.72 | CETP (0.39) | CETPCSNK1ECNR2 | |
| SCHEMBL7925674 | 0.72 | KDM4E (0.38) | CETPCNR2 | |
| SCHEMBL7928566 | 0.71 | MMP1 (0.34) | — | |
| SCHEMBL7606682 | 0.71 | MMP1 (0.35) | CETP | |
| SCHEMBL7928376 | 0.69 | CETP (0.39) | CETPCSNK1ECNR2ENPP2DGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994707-A4 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARM INC (US) | 2001-11-14 | — | — | EP | disclosed |
| EP-0994707-A1 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998053812-A1 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1998-12-03 | — | — | WO | disclosed |