Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 10/20 | 0.34 |
| ▸ | MMP13 | P45452 | 5/20 | 0.34 |
| ▸ | MMP3 | P08254 | 4/20 | 0.34 |
| ▸ | MMP2 | P08253 | 4/20 | 0.34 |
| ▸ | MMP8 | P22894 | 2/20 | 0.34 |
| ▸ | MMP12 | P39900 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7928430 | 0.81 | CETP (0.36) | MMP1MMP3MMP2 | |
| SCHEMBL7607525 | 0.76 | MMP1 (0.37) | MMP1MMP13MMP3MMP2MMP8 | |
| SCHEMBL7606830 | 0.75 | RAB9A (0.35) | MMP1MMP13MMP3MMP2MMP8 | |
| SCHEMBL7605208 | 0.74 | ALDH1A1 (0.34) | MMP1MMP13MMP3MMP2MMP8 | |
| SCHEMBL7606682 | 0.73 | MMP1 (0.35) | MMP1MMP13MMP3MMP2MMP8 | |
| SCHEMBL5054449 | 0.71 | OPRM1 (0.39) | OPRM1OPRD1OPRK1 | |
| SCHEMBL7606725 | 0.71 | MMP1 (0.38) | MMP1MMP13MMP3MMP2MMP8 | |
| SCHEMBL7929167 | 0.71 | CETP (0.37) | — | |
| SCHEMBL8423445 | 0.70 | PGK1 (0.33) | MMP1MMP13MMP3HPGD | |
| SCHEMBL7606131 | 0.70 | HPGD (0.33) | MMP1OPRM1OPRD1OPRK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994707-A4 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARM INC (US) | 2001-11-14 | — | — | EP | claimed |
| EP-0994707-A1 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-26 | — | — | EP | claimed |
| WO-1998053812-A1 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1998-12-03 | — | — | WO | claimed |