Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 4/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.34 |
| ▸ | CTSG | P08311 | 2/20 | 0.34 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.34 |
| ▸ | CMA1 | P23946 | 2/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7929167 | 0.86 | CETP (0.37) | CETPCNR2CSNK1EPRSS1CTSG | |
| SCHEMBL7928566 | 0.81 | MMP1 (0.34) | MMP1MMP2MMP3 | |
| SCHEMBL7928376 | 0.77 | CETP (0.39) | CETPCNR2CSNK1EPRSS1CTSG | |
| SCHEMBL7920074 | 0.75 | DRD2 (0.39) | CETPMMP2MMP3PPARGPPARA | |
| SCHEMBL5051174 | 0.74 | CETP (0.38) | CETPCNR2CSNK1EMMP2MMP3 | |
| SCHEMBL7926749 | 0.74 | PTPN1 (0.43) | CETPMMP1PPARGPPARA | |
| SCHEMBL5053060 | 0.74 | CETP (0.39) | CETPCNR2CSNK1ECNR1 | |
| SCHEMBL5053184 | 0.74 | CETP (0.39) | CETPCNR2CSNK1E | |
| SCHEMBL6037795 | 0.73 | CETP (0.34) | CETPMMP1 | |
| SCHEMBL7606725 | 0.73 | MMP1 (0.38) | CETPMMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994707-A4 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARM INC (US) | 2001-11-14 | — | — | EP | disclosed |
| EP-0994707-A1 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998053812-A1 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1998-12-03 | — | — | WO | disclosed |