Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL134295 | 0.96 | CA4 (0.53) | CA4CA1TDP1ALDH1A1FAHD1 | |
| Methacrylic Acid SCHEMBL28133672 | 0.93 | — | — | |
| Methacrylic Acid SCHEMBL27924121 | 0.93 | — | — | |
| Methacrylic Acid SCHEMBL10975727 | 0.93 | CA4 (0.50) | CA4CA1TDP1ALDH1A1FAHD1 | |
| Methacrylic Acid SCHEMBL11653396 | 0.93 | — | — | |
| Methacrylic Acid SCHEMBL28054384 | 0.93 | CA4 (0.50) | CA4CA1TDP1ALDH1A1FAHD1 | |
| Methacrylic Acid SCHEMBL7930287 | 0.93 | — | — | |
| Methacrylic Acid SCHEMBL28124744 | 0.93 | CA4 (0.50) | CA4CA1TDP1ALDH1A1FAHD1 | |
| Methacrylic Acid SCHEMBL19384595 | 0.93 | CA4 (0.57) | CA4CA1TDP1ALDH1A1FAHD1 | |
| Methacrylic Acid SCHEMBL59390 | 0.93 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010021449-A1 | Foamed rubber, process for producing the same and composite comprising the foamed rubber | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2001-09-13 | — | — | US | disclosed |