SCHEMBL7931028

SCHEMBL7931028

O=C(Cl)c1cc(Cl)c(Cl)cc1F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.46
ALOX15 P16050 1/20 0.46
POLB P06746 1/20 0.40
APEX1 P27695 1/20 0.40
HPGD P15428 3/20 0.39
TSHR P16473 2/20 0.38
MAPT P10636 1/20 0.38
SLC9A1 P19634 1/20 0.37
CES2 O00748 1/20 0.37
CES1 P23141 1/20 0.37
KEAP1 Q14145 1/20 0.36
NFE2L2 Q16236 1/20 0.36
SLC2A1 P11166 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
PLAU P00749 1/20 0.34
ELANE P08246 1/20 0.34
SCN9A Q15858 2/20 0.33
PYGL P06737 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30180915 0.88 ALDH1A1 (0.45) ALDH1A1ALOX15POLBAPEX1HPGD
SCHEMBL9793665 0.88 ALDH1A1 (0.45) ALDH1A1ALOX15POLBAPEX1HPGD
SCHEMBL24710385 0.85 ALDH1A1 (0.54) ALDH1A1ALOX15POLBAPEX1HPGD
SCHEMBL7929417 0.84 ALDH1A1 (0.45) ALDH1A1ALOX15POLBAPEX1HPGD
SCHEMBL3336346 0.83 ALDH1A1 (0.41) ALDH1A1ALOX15POLBAPEX1HPGD
SCHEMBL22311224 0.83 ALDH1A1 (0.41) ALDH1A1ALOX15POLBAPEX1HPGD
SCHEMBL8183434 0.83 KDM4E (0.42) ALDH1A1ALOX15POLBAPEX1HPGD
SCHEMBL7656107 0.82 ALDH1A1 (0.42) ALDH1A1ALOX15POLBHPGDTSHR
SCHEMBL9025713 0.81 POLB (0.42) ALDH1A1ALOX15POLBAPEX1HPGD
SCHEMBL3820327 0.81 POLB (0.53) ALDH1A1ALOX15POLBAPEX1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024153856-A1 PROCESS FOR THE PREPARATION OF 3-(4,5-DICHLORO-2-(4-(TRIFLUOROMETHOXY)PHENOXY)BENZAMIDO)PYRIDINE 1-OXIDE ORION CORPORATION (FI) 2024-07-25 WO claimed
US-12281057-B2 Carboxamides as modulators of sodium channels VERTEX PHARMACEUTICALS INCORPORATED (US) 2025-04-22 US disclosed
EP-3651752-B1 CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMA (US) 2024-11-20 EP disclosed
WO-2024153856-A1 PROCESS FOR THE PREPARATION OF 3-(4,5-DICHLORO-2-(4-(TRIFLUOROMETHOXY)PHENOXY)BENZAMIDO)PYRIDINE 1-OXIDE ORION CORPORATION (FI) 2024-07-25 WO disclosed
US-20230286907-A1 CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-09-14 US disclosed
US-20230286907-A1 CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-09-14 US disclosed
US-20230286907-A1 CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-09-14 US disclosed
CN-112955436-B 6-oxo-1, 6-dihydropyridazine derivatives, preparation method and application thereof in medicines 福建盛迪医药有限公司 2023-08-11 CN disclosed
US-11603351-B2 Carboxamides as modulators of sodium channels VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-03-14 US disclosed
US-20220073471-A1 6-OXO-1,6-DIHYDROPYRIDAZINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF JIANGSU HENGRUI MEDICINE CO (CN) 2022-03-10 US disclosed
WO-2014120820-A9 AMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMACEUTICALS INCORPORATED (US) 2015-07-02 WO disclosed
US-20140221435-A1 AMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMACEUTICALS INCORPORATED (US) 2014-08-07 US disclosed
WO-2014120820-A1 AMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMACEUTICALS INCORPORATED (US) 2014-08-07 WO disclosed
EP-1140735-A1 PREPARATION OF NUCLEAR CHLORINATED AROMATIC COMPOUNDS OCCIDENTAL CHEMICAL CORPORATION (US) 2001-10-10 EP disclosed
WO-2000040524-A1 PREPARATION OF NUCLEAR CHLORINATED AROMATIC COMPOUNDS OCCIDENTAL CHEMICAL CORPORATION (US) 2000-07-13 WO disclosed
US-5981789-A CHLORODENITRATING AROMATIC COMPOUNDS USING LESS CHLORINATING AGENT AND LOWER TEMPERATURES, THEN RECYCLING THE PRODUCT MIXTURE TO INCREASE THE YIELD OCCIDENTAL CHEMICAL CORPORATION (US) 1999-11-09 US disclosed
US-4704483-A FLUORINATION WITH POTASSIUM FLUORIDE OCCIDENTAL CHEMICAL CORPORATION (US) 1987-11-03 US disclosed
US-4582948-A VAPOR PHASE CHLORO-DENITRATION REACTION OCCIDENTAL CHEMICAL CORPORATION (US) 1986-04-15 US disclosed
EP-0159388-A2 Preparation of nuclear chlorinated compounds OCCIDENTAL CHEMICAL CORPORATION (US) 1985-10-30 EP disclosed
US-4470930-A Preparation of nuclear chlorinated aromatic compounds OCCIDENTAL CHEMICAL CORPORATION (US) 1984-09-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220073471-A1 6-OXO-1,6-DIHYDROPYRIDAZINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF CACNA1D, CACNA1F, CACNA1B ALDH1A1 268/4885ALOX15 148/4885POLB 3655/4885
US-11603351-B2 Carboxamides as modulators of sodium channels TRPV1, SCN2A, SCN10A ALDH1A1 2665/4885ALOX15 3043/4885POLB 4797/4885
US-20140221435-A1 AMIDES AS MODULATORS OF SODIUM CHANNELS SCN1A, SCN5A, TRPV1 ALDH1A1 1545/4885ALOX15 2045/4885POLB 4809/4885
US-20230286907-A1 CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS TRPV1, SCN2A, SCN10A ALDH1A1 2665/4885ALOX15 3043/4885POLB 4797/4885
US-12281057-B2 Carboxamides as modulators of sodium channels TRPV1, SCN2A, SCN10A ALDH1A1 2665/4885ALOX15 3043/4885POLB 4797/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.