Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1180396 | 0.91 | ALDH1A1 (0.45) | ALDH1A1ALOX15POLBAPEX1HPGD | |
| SCHEMBL3820327 | 0.88 | POLB (0.53) | ALDH1A1ALOX15POLBAPEX1HPGD | |
| SCHEMBL9793665 | 0.86 | ALDH1A1 (0.45) | ALDH1A1ALOX15POLBAPEX1HPGD | |
| SCHEMBL30180915 | 0.86 | ALDH1A1 (0.45) | ALDH1A1ALOX15POLBAPEX1HPGD | |
| SCHEMBL101268 | 0.85 | TSHR (0.42) | ALDH1A1ALOX15POLBHPGDTSHR | |
| SCHEMBL7931028 | 0.84 | ALDH1A1 (0.46) | ALDH1A1ALOX15POLBAPEX1HPGD | |
| SCHEMBL364382 | 0.82 | KEAP1 (0.48) | ALDH1A1POLBAPEX1HPGDTSHR | |
| SCHEMBL13445696 | 0.81 | ALDH1A1 (0.41) | ALDH1A1ALOX15POLBAPEX1HPGD | |
| SCHEMBL15385122 | 0.81 | POLB (0.43) | ALDH1A1ALOX15POLBAPEX1HPGD | |
| SCHEMBL1312984 | 0.80 | TSHR (0.39) | ALDH1A1ALOX15POLBHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11161818-B2 | Quinolone derivatives, preparation methods and application thereof | HANGZHOU NORMAL UNIVERSITY (CN) | 2021-11-02 | — | — | US | disclosed |
| US-20210198207-A1 | QUINOLONE DERIVATIVES, PREPARATION METHODS AND APPLICATION THEREOF | HANGZHOU NORMAL UNIVERSITY (CN) | 2021-07-01 | — | — | US | disclosed |
| EP-1140735-A1 | PREPARATION OF NUCLEAR CHLORINATED AROMATIC COMPOUNDS | OCCIDENTAL CHEMICAL CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040524-A1 | PREPARATION OF NUCLEAR CHLORINATED AROMATIC COMPOUNDS | OCCIDENTAL CHEMICAL CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |
| US-5981789-A | CHLORODENITRATING AROMATIC COMPOUNDS USING LESS CHLORINATING AGENT AND LOWER TEMPERATURES, THEN RECYCLING THE PRODUCT MIXTURE TO INCREASE THE YIELD | OCCIDENTAL CHEMICAL CORPORATION (US) | 1999-11-09 | — | — | US | disclosed |
| US-4704483-A | FLUORINATION WITH POTASSIUM FLUORIDE | OCCIDENTAL CHEMICAL CORPORATION (US) | 1987-11-03 | — | — | US | disclosed |
| US-4582948-A | VAPOR PHASE CHLORO-DENITRATION REACTION | OCCIDENTAL CHEMICAL CORPORATION (US) | 1986-04-15 | — | — | US | disclosed |
| EP-0159388-A2 | Preparation of nuclear chlorinated compounds | OCCIDENTAL CHEMICAL CORPORATION (US) | 1985-10-30 | — | — | EP | disclosed |
| US-4470930-A | Preparation of nuclear chlorinated aromatic compounds | OCCIDENTAL CHEMICAL CORPORATION (US) | 1984-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11161818-B2 | Quinolone derivatives, preparation methods and application thereof | NQO2, MRPL21, TOP1 | ALDH1A1 3449/4885ALOX15 3493/4885POLB 411/4885 |
| US-20210198207-A1 | QUINOLONE DERIVATIVES, PREPARATION METHODS AND APPLICATION THEREOF | NQO2, MRPL21, TOP1 | ALDH1A1 3449/4885ALOX15 3493/4885POLB 411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.