Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 10/20 | 0.82 |
| ▸ | NOS1 | P29475 | 8/20 | 0.82 |
| ▸ | NOS3 | P29474 | 2/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | JAK1 | P23458 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8379798 | 0.99 | NOS2 (0.80) | NOS2NOS1NOS3KCNH2JAK2 | |
| SCHEMBL7931849 | 0.91 | NOS2 (0.87) | NOS2NOS1NOS3KCNH2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8379849 | 0.90 | NOS2 (0.85) | NOS2NOS1NOS3KCNH2ALDH1A1 | |
| SCHEMBL7940883 | 0.90 | NOS2 (1.00) | NOS2NOS1NOS3KCNH2ALDH1A1 | |
| SCHEMBL7931756 | 0.90 | NOS2 (0.84) | NOS2NOS1NOS3KCNH2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8379951 | 0.89 | NOS2 (0.98) | NOS2NOS1NOS3KCNH2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8376625 | 0.89 | NOS2 (0.82) | NOS2NOS1NOS3KCNH2ALDH1A1 | |
| SCHEMBL7931921 | 0.89 | NOS2 (1.00) | NOS2NOS1NOS3KCNH2JAK2 | |
| SCHEMBL7938128 | 0.89 | NOS2 (0.82) | NOS2NOS1NOS3KCNH2ALDH1A1 | |
| SCHEMBL7939610 | 0.89 | NOS2 (0.76) | NOS2NOS1NOS3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248745-B1 | MIXTURE COMPRISING A CYCLOOXYGENASE-2 (COX-2) INHIBITOR AND A 1,2-DIHYDRO-4-AMINOQUINAZOLINE DERIVATIVE INHIBITOR OF INDUCED NITRIC OXIDE SYNTHASE (INOS); NON-STEROIDAL ANTIINFLAMMATORY AGENTS | ASTRAZENECA AB (SE) | 2001-06-19 | — | — | US | claimed |