SCHEMBL7932075

SCHEMBL7932075

COc1ccc(-c2cc(C(F)F)nn2NS(=O)(=O)c2ccccc2)cc1F

nearest known ligand 0.56

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 11/20 0.56
PTGS1 P23219 9/20 0.56
ABCB11 O95342 1/20 0.56
ALDH1A1 P00352 1/20 0.56
SCN9A Q15858 1/20 0.39
PI4KB Q9UBF8 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzenesulfonamide SCHEMBL7046453 0.95 PTGS2 (0.65) PTGS2PTGS1ABCB11ALDH1A1
SCHEMBL8688528 0.92 PTGS2 (0.46) PTGS2PTGS1ABCB11ALDH1A1
SCHEMBL8691588 0.91 PTGS2 (0.46) PTGS2PTGS1ABCB11ALDH1A1SCN9A
SCHEMBL8693376 0.89 PTGS2 (0.57) PTGS2PTGS1ABCB11ALDH1A1
SCHEMBL8688815 0.89 PTGS1 (0.46) PTGS2PTGS1ABCB11ALDH1A1
SCHEMBL8691532 0.88 PTGS2 (0.55) PTGS2PTGS1ABCB11ALDH1A1
Benzenesulfonamide SCHEMBL8163191 0.85 PTGS2 (0.53) PTGS2PTGS1ABCB11ALDH1A1
SCHEMBL8688398 0.85 PTGS1 (0.53) PTGS2PTGS1ABCB11ALDH1A1
SCHEMBL8640455 0.84 PTGS2 (0.45) PTGS2PTGS1ABCB11ALDH1A1SCN9A
SCHEMBL8692192 0.84 PTGS2 (0.42) PTGS2PTGS1ABCB11ALDH1A1SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2001527542-A 2001-12-25 JP claimed
EP-0979077-A1 METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE PREVENTION OF CARDIOVASCULAR DISORDERS G.D. Searle & Co. (US) 2000-02-16 EP claimed
US-5910597-A Process for preparing 3-haloalkyl-1H-pyrazoles G.D. SEARLE & CO. (US) 1999-06-08 US claimed
US-5892053-A Process for preparing 3-haloalkyl-1H-pyrazoles G. D. SEARLE & CO. (US) 1999-04-06 US claimed
WO-1998047509-A1 METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE PREVENTION OF CARDIOVASCULAR DISORDERS G.D. SEARLE & CO. (US) 1998-10-29 WO claimed
US-5760068-A NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS G.D. SEARLE & CO. (US) 1998-06-02 US claimed
US-5700816-A ANTIARTHRITIC AGENTS G.D. SEARLE & CO. 1997-12-23 US claimed
US-5910597-A Process for preparing 3-haloalkyl-1H-pyrazoles G.D. SEARLE & CO. (US) 1999-06-08 US disclosed
US-5892053-A Process for preparing 3-haloalkyl-1H-pyrazoles G. D. SEARLE & CO. (US) 1999-04-06 US disclosed
US-5760068-A NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS G.D. SEARLE & CO. (US) 1998-06-02 US disclosed
US-5756529-A ANTIINFLAMMATORY G.D. SEARLE & CO. (US) 1998-05-26 US disclosed
US-5753688-A ANTIINFLAMMATORY TALLEY JOHN J (US) 1998-05-19 US disclosed
US-5700816-A ANTIARTHRITIC AGENTS G.D. SEARLE & CO. 1997-12-23 US disclosed