Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 10/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8640455 | 0.93 | PTGS2 (0.45) | PTGS2PTGS1ABCB11ALDH1A1SCN9A | |
| SCHEMBL8689604 | 0.91 | PTGS2 (0.41) | PTGS2PTGS1ABCB11ALDH1A1HPGD | |
| Benzenesulfonamide SCHEMBL7192191 | 0.88 | PTGS2 (0.53) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL8637024 | 0.84 | PTGS2 (0.54) | PTGS2PTGS1HPGDHTT | |
| SCHEMBL7932075 | 0.84 | PTGS2 (0.56) | PTGS2PTGS1ABCB11ALDH1A1SCN9A | |
| SCHEMBL8691588 | 0.83 | PTGS2 (0.46) | PTGS2PTGS1ABCB11ALDH1A1SCN9A | |
| SCHEMBL8639246 | 0.82 | PTGS2 (0.56) | PTGS2PTGS1ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL8689324 | 0.82 | PTGS2 (0.45) | PTGS2PTGS1ALDH1A1SCN9A | |
| SCHEMBL8694127 | 0.81 | PTGS2 (0.57) | PTGS2PTGS1HPGDL3MBTL1SCN9A | |
| SCHEMBL8689085 | 0.80 | PTGS2 (0.44) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |