Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzenesulfonamide SCHEMBL7192191 | 0.95 | PTGS2 (0.53) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL8692192 | 0.93 | PTGS2 (0.42) | PTGS2PTGS1ABCB11ALDH1A1SCN9A | |
| SCHEMBL8689604 | 0.92 | PTGS2 (0.41) | PTGS2PTGS1ABCB11ALDH1A1SCN9A | |
| SCHEMBL8637024 | 0.92 | PTGS2 (0.54) | PTGS2PTGS1MAPTPOLBTHRB | |
| SCHEMBL8639246 | 0.90 | PTGS2 (0.56) | PTGS2PTGS1MAPTPOLBTHRB | |
| SCHEMBL8689324 | 0.89 | PTGS2 (0.45) | PTGS2PTGS1MAPTPOLBTHRB | |
| SCHEMBL8694127 | 0.88 | PTGS2 (0.57) | PTGS2PTGS1MAPTPOLBTHRB | |
| SCHEMBL8689085 | 0.87 | PTGS2 (0.44) | PTGS2PTGS1MAPTTHRBSMN1; SMN2 | |
| SCHEMBL8691235 | 0.85 | PTGS2 (0.50) | PTGS2PTGS1MAPTPOLBTHRB | |
| SCHEMBL8688621 | 0.85 | PTGS2 (0.42) | PTGS2PTGS1MAPTPOLBTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |