Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7942482 | 0.87 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2KDM4EPOLBNPC1 | |
| SCHEMBL24485258 | 0.85 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2KDM4EPOLBNPC1 | |
| SCHEMBL6177219 | 0.84 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2KDM4EPOLBNPC1 | |
| SCHEMBL3618933 | 0.80 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2KDM4EPOLBNPC1 | |
| SCHEMBL7941573 | 0.78 | RAB9A (0.59) | ALDH1A1SMN1; SMN2POLBRAB9AHTT | |
| SCHEMBL7941960 | 0.77 | P2RX7 (0.46) | KDM4ENPC1RAB9AMEN1KMT2A | |
| SCHEMBL4177078 | 0.75 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2KDM4EPOLBNPC1 | |
| SCHEMBL6176174 | 0.75 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2KDM4EPOLBNPC1 | |
| SCHEMBL10757128 | 0.75 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2KDM4EPOLBNPC1 | |
| SCHEMBL6977861 | 0.75 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2KDM4EPOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |