Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 7/20 | 0.37 |
| ▸ | SLC6A3 known ✓ | Q01959 | 7/20 | 0.37 |
| ▸ | HRH1 | P35367 | 3/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.37 |
| ▸ | HTR1A | P08908 | 5/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7932246 | 0.78 | HRH1 (0.44) | HRH1SLC6A4SLC6A2SLC6A3HTR1A | |
| Hydrochloric Acid SCHEMBL7934442 | 0.77 | HRH1 (0.37) | HRH1SLC6A4SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL7934926 | 0.77 | SMN1; SMN2 (0.43) | SLC6A2SLC6A3HTR1A | |
| Hydrochloric Acid SCHEMBL7934542 | 0.76 | HRH1 (0.43) | HRH1SLC6A4SLC6A2SLC6A3HTR1A | |
| Hydrochloric Acid SCHEMBL7936195 | 0.76 | SLC18A3 (0.44) | HRH1SLC6A4SLC6A2HTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL7932281 | 0.73 | SLC6A2 (0.41) | HRH1SLC6A2SLC6A3CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL7938247 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL7932333 | 0.70 | CHRNB2 (0.41) | HTR2CHTR2BSLC18A3SIGMAR1CHRNB2 | |
| SCHEMBL29735458 | 0.69 | HRH1 (0.85) | HRH1SLC6A4SLC6A2SLC6A3HTR1A | |
| SCHEMBL211130 | 0.68 | HRH1 (1.00) | HRH1SLC6A4SLC6A2SLC6A3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6169152-B1 | COPOLYMER OF ETHYLENE AND A POLAR GROUP-CONTAINING CYCLIC OLEFIN COMPRISING ESTER- OR ANHYDRIDE MODIFIED NORBORNENE OR PERHYDRO-2,3-DIDEHYDRO-1,4:5,8-DIMETHANONAPHTHALENE MADE WITH CATALYST SUCH AS 1,5,9-TRIAZACYCLODODECANYLTITANIUM CHLORIDE | JSR CORPORATION (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0816387-A1 | Olefin-polymerizing catalyst | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1998-01-07 | — | — | EP | disclosed |