SCHEMBL7932298

SCHEMBL7932298

COc1ccc(C(Cl)CC(F)(F)F)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.48
TSHR P16473 1/20 0.48
MAPK1 P28482 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
CA12 O43570 1/20 0.41
CA7 P43166 1/20 0.41
CA9 Q16790 1/20 0.41
CA14 Q9ULX7 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C19 P33261 1/20 0.41
AOC3 Q16853 3/20 0.39
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
GAA P10253 2/20 0.38
MAPT P10636 1/20 0.38
SLC2A1 P11166 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9227730 0.79 CHRNA7 (0.35) ALDH1A1TSHRTDP1CA1CA2
SCHEMBL3262355 0.78 AOC3 (0.54) ALDH1A1TSHRMAPK1TDP1L3MBTL1
SCHEMBL7109235 0.76 ALDH1A1 (0.50) ALDH1A1TSHRMAPK1TDP1L3MBTL1
SCHEMBL10481599 0.76 ALDH1A1 (0.50) ALDH1A1TSHRMAPK1TDP1L3MBTL1
SCHEMBL9226244 0.76 TSHR (0.43) ALDH1A1TSHRMAPK1TDP1L3MBTL1
SCHEMBL11065539 0.75 MAPK1 (0.42) ALDH1A1TSHRMAPK1TDP1L3MBTL1
SCHEMBL7605180 0.75 MAPK1 (0.53) ALDH1A1TSHRMAPK1TDP1L3MBTL1
SCHEMBL20969742 0.75 CYP1A2 (0.48) ALDH1A1TSHRMAPK1TDP1L3MBTL1
SCHEMBL28271308 0.75 ALDH1A1 (0.48) ALDH1A1TSHRMAPK1TDP1L3MBTL1
SCHEMBL9220265 0.74 TSHR (0.44) ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE37087-E1 1-(4-ETHOXYPHENYL)-4-(4-FLUORO-3-PHENOXYPHENYL)-1 -TRIFLUOROMETHYLBUTANE OR 1-(4-ETHOXY-3-FLUOROPHENYL)-4-(3-PHENOXYPHENYL)-1-TRIFLUOROMETHYLBUTANE, FOR EXAMPLE; COMBATS INSECTS AND MITES SCHERING AKTIENGESELLSCHAFT (DE) 2001-03-06 US disclosed
EP-0233834-B1 INSECTICIDAL TRIFLUORMETHYL ALKANE DERIVATIVES SCHERING AKTIENGESELLSCHAFT (DE) 1992-04-22 EP disclosed
US-4791123-A MITICIDES SCHERING AKT. (DE) 1988-12-13 US disclosed
EP-0233834-A1 Insecticidal trifluormethyl alkane derivatives SCHERING AKTIENGESELLSCHAFT (DE) 1987-08-26 EP disclosed