SCHEMBL7932418

SCHEMBL7932418

CC(C)(C)c1ccc2c(c1C#N)C(=O)NC2=O

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 3/20 0.36
KDM4E B2RXH2 4/20 0.35
ALDH1A1 P00352 3/20 0.35
GAA P10253 3/20 0.35
HPGD P15428 3/20 0.35
GLA P06280 2/20 0.35
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
PPOX P50336 1/20 0.33
HSD17B10 Q99714 1/20 0.33
DHODH Q02127 1/20 0.32
MGAT2 Q10469 1/20 0.32
WEE1 P30291 2/20 0.31
GSK3B P49841 1/20 0.31
CHEK1 O14757 1/20 0.31
TP53 P04637 1/20 0.30
GRM5 P41594 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11426926 0.76 PARP1 (0.42) PARP1KDM4EALDH1A1GAAHPGD
SCHEMBL1860679 0.76 PARP1 (0.40) PARP1KDM4EALDH1A1GAAHPGD
SCHEMBL2156113 0.70 KDM4E (0.47) PARP1KDM4EALDH1A1GAAHPGD
SCHEMBL26259669 0.67 ALDH1A1 (0.34) KDM4EALDH1A1GAAHPGDGLA
SCHEMBL29212758 0.66 PARP1 (0.42) PARP1KDM4EALDH1A1GAAHPGD
SCHEMBL30884125 0.66 PARP1 (0.42) PARP1KDM4EALDH1A1GAAHPGD
SCHEMBL13606488 0.66 PARP1 (0.35) PARP1KDM4EMEN1KMT2APPOX
Bicarbonate SCHEMBL23581765 0.66 KDM4E (0.50) PARP1KDM4EALDH1A1GAAHPGD
SCHEMBL9632335 0.65 PARP1 (0.41) PARP1PPOXWEE1GSK3BCHEK1
SCHEMBL21451350 0.64 CA2 (0.48) KDM4EALDH1A1GAAHPGDGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6191307-B1 Process for making benzoic acids ALBEMARLE CORPORATION 2001-02-20 US disclosed