Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 3/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16226687 | 0.86 | TACR1 (0.52) | CCR3TACR1 | |
| SCHEMBL7989488 | 0.86 | TACR1 (0.49) | LMNASMN1; SMN2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL7925814 | 0.85 | CCR3 (0.50) | LMNACCR3TACR1 | |
| SCHEMBL7988909 | 0.83 | FAAH (0.51) | LMNAALDH1A1L3MBTL1CCR3OPRD1 | |
| SCHEMBL8671441 | 0.80 | LMNA (0.49) | LMNASMN1; SMN2ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL8671447 | 0.79 | LMNA (0.48) | LMNASMN1; SMN2ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL7932641 | 0.79 | CCR3 (0.57) | CCR3TACR1 | |
| SCHEMBL7987228 | 0.78 | CCR3 (0.67) | CCR3TACR1 | |
| SCHEMBL7934776 | 0.78 | TACR1 (0.57) | CCR3TACR1 | |
| SCHEMBL7926034 | 0.78 | TACR1 (0.48) | CCR3OPRD1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191135-B1 | Neurokinin antagonists | BOEHRINGER INGELHEIM KG (DE) | 2001-02-20 | — | — | US | claimed |
| US-6235732-B1 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; SKIN DISORDERS | BOEHRINGER INGELHEIM KG (DE) | 2001-05-22 | — | — | US | disclosed |
| US-6191135-B1 | Neurokinin antagonists | BOEHRINGER INGELHEIM KG (DE) | 2001-02-20 | — | — | US | disclosed |
| US-5985881-A | TREATMENT AND PREVENTION OF RESPIRATORY DISORDERS, INFLAMMATORY EYE DISEASES, INFLAMMATORY SKIN DISEASES, INTESTINAL DISORDERS, OTHER INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM KG (DE) | 1999-11-16 | — | — | US | disclosed |
| US-5708006-A | ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM KG (DE) | 1998-01-13 | — | — | US | disclosed |
| US-5696123-A | ALPHA-PIPERAZINYL BENZYL COMPOUND AS TACHYKININ ANTAGONIST TREATING ASTHMA, BRONCHITIS, SKIN DISORDER, EYE DISEASE, HEADACHE, GASTROINTESTINAL DISORDER | BOEHRINGER INGELHEIM KG (DE) | 1997-12-09 | — | — | US | disclosed |