Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.47 |
| ▸ | HTR1D | P28221 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 7/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.43 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9509332 | 1.00 | PARP2 (0.47) | PARP2HTR1DPARP1HTR7NPC1 | |
| SCHEMBL7926494 | 0.99 | HTR7 (0.47) | PARP2HTR1DPARP1HTR7NPC1 | |
| SCHEMBL7935545 | 0.89 | HTR7 (0.51) | HTR1DHTR7HTR1ATP53BP1L3MBTL3 | |
| SCHEMBL7932845 | 0.84 | KDM4E (0.49) | HTR1DHTR7HTR1ATP53BP1L3MBTL3 | |
| SCHEMBL11072209 | 0.79 | HTR7 (0.69) | HTR1DHTR7HTR1A | |
| SCHEMBL7932835 | 0.79 | HTR7 (0.69) | HTR1DHTR7HTR1A | |
| Hydrochloric Acid SCHEMBL7926756 | 0.78 | HTR7 (0.67) | HTR1DHTR7HTR1A | |
| SCHEMBL14591337 | 0.75 | HTR1D (0.51) | HTR1DHTR7HTR1A | |
| SCHEMBL14591377 | 0.75 | HTR1D (0.51) | HTR1DHTR7HTR1A | |
| SCHEMBL7935409 | 0.75 | HTR1D (0.51) | HTR1DHTR7HTR1AL3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992006967-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1992-04-30 | — | — | WO | claimed |
| US-6331636-B1 | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, DIABETES, HYPERTENSION, IMPOTENCY, APPETITE CONTROL | THE UPJOHN COMPANY | 2001-12-18 | — | — | US | disclosed |
| US-5545755-A | USEFUL TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS, HYPERTENSION, DIABETES, SEXUAL IMPOTENCY AND TO CONTROL APPETITE | THE UPJOHN COMPANY (US) | 1996-08-13 | — | — | US | disclosed |
| EP-0552246-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 1993-07-28 | — | — | EP | disclosed |
| WO-1992006967-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1992-04-30 | — | — | WO | disclosed |