Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 2/20 | 0.44 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7935545 | 0.86 | HTR7 (0.51) | HTR1DHTR7HTR1AOPRK1MEN1 | |
| SCHEMBL9509332 | 0.84 | PARP2 (0.47) | HTR1DHTR7HTR1ATP53BP1L3MBTL3 | |
| SCHEMBL7932829 | 0.84 | PARP2 (0.47) | HTR1DHTR7HTR1ATP53BP1L3MBTL3 | |
| SCHEMBL7926494 | 0.82 | HTR7 (0.47) | HTR1DHTR7HTR1ATP53BP1L3MBTL3 | |
| SCHEMBL8677765 | 0.79 | SIGMAR1 (0.54) | HTR1DDRD2 | |
| SCHEMBL11393302 | 0.79 | SIGMAR1 (0.54) | HTR1DDRD2 | |
| Hydrochloric Acid SCHEMBL7933015 | 0.78 | SIGMAR1 (0.53) | HTR1DDRD2 | |
| Hydrochloric Acid SCHEMBL7935858 | 0.78 | SIGMAR1 (0.53) | HTR1DDRD2 | |
| SCHEMBL4215401 | 0.78 | CHRM2 (0.55) | HTR1DDRD2 | |
| SCHEMBL8672548 | 0.77 | SLC18A3 (0.52) | HTR1DHTR7ALDH1A1HTR1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331636-B1 | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, DIABETES, HYPERTENSION, IMPOTENCY, APPETITE CONTROL | THE UPJOHN COMPANY | 2001-12-18 | — | — | US | disclosed |
| US-5545755-A | USEFUL TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS, HYPERTENSION, DIABETES, SEXUAL IMPOTENCY AND TO CONTROL APPETITE | THE UPJOHN COMPANY (US) | 1996-08-13 | — | — | US | disclosed |
| EP-0552246-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 1993-07-28 | — | — | EP | disclosed |
| WO-1992006967-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1992-04-30 | — | — | WO | disclosed |