Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7930304 | 0.87 | DRD2 (0.48) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL22005149 | 0.87 | DRD2 (0.47) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL30580523 | 0.77 | DRD2 (0.63) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL7533056 | 0.76 | DRD2 (0.44) | DRD2DRD3DRD4DRD1 | |
| SCHEMBL7533054 | 0.76 | DRD2 (0.44) | DRD2DRD3DRD4DRD1 | |
| SCHEMBL7933904 | 0.76 | DRD2 (0.43) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL7450114 | 0.73 | DRD2 (0.61) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL4101579 | 0.73 | DRD3 (0.45) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL4100155 | 0.73 | DRD3 (0.45) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL4110551 | 0.73 | DRD3 (0.45) | DRD2DRD3DRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6232348-B1 | AGONISTS OF THE DOPAMINERGIC RECEPTORS MORE POTENT THAN DOPAMINE AND OTHER KNOWN COMPOUNDS, DEPRIVED OF INTERACTION WITH OTHER RECEPTORS AND ORALLY BIOAVAILABLE WITH A LONG TERM OF ACTION | ZAMBON GROUP S.P.A. (IT) | 2001-05-15 | — | — | US | disclosed |