Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7942653 | 0.83 | BACE1 (0.46) | BACE1BACE2 | |
| SCHEMBL7943969 | 0.82 | PRKCI (0.47) | BACE1BACE2 | |
| SCHEMBL16472030 | 0.79 | BACE1 (0.55) | BACE1BACE2CTSD | |
| SCHEMBL7940427 | 0.79 | SMN1; SMN2 (0.48) | BACE1BACE2 | |
| SCHEMBL7942651 | 0.78 | BACE1 (0.47) | BACE1CYP2D6BACE2 | |
| SCHEMBL7945287 | 0.75 | GRM4 (0.48) | BACE1CYP2D6BACE2 | |
| SCHEMBL7942303 | 0.74 | NPC1 (0.53) | — | |
| SCHEMBL21442234 | 0.74 | BACE1 (0.46) | BACE1BACE2 | |
| SCHEMBL21442433 | 0.73 | BACE1 (0.46) | BACE1BACE2CTSD | |
| SCHEMBL21442265 | 0.73 | BACE1 (0.46) | BACE1CYP2D6BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010047372-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | 塩野義製薬株式会社 (JP) | 2010-04-29 | — | — | WO | disclosed |